Applying PET/MR in Rectal Cancer.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Rectal Cancer
- Sponsor
- Tel-Aviv Sourasky Medical Center
- Enrollment
- 20
- Primary Endpoint
- Number of patient that shown the different between diagnostic value of single PET/MR scan in RC staging and compare it to that of MRI alone, PET/CT alone, and combined MRI and PET/CT
- Last Updated
- 6 years ago
Overview
Brief Summary
The use of the novel recently introduced PET/MR scanner is believed to be promising in RC management, providing great anatomical details and detailed metabolic characterization. Preliminary data indicate it may become a strong imaging modality for staging of RC and has the potential to be used as a predictive tool guiding individualized therapy in patients receiving nT, but confirmation on prospective studies is mandatory. The use of radiomics as analysis approach may assist in achieving a better understanding of the obtained image data, and thus a more accurate disease assessment.
Objectives
- To preliminary assess the potential diagnostic value of single PET/MR scan in RC staging and compare it to that of MRI alone, PET/CT alone, and combined MRI and PET/CT.
- To preliminary assess the potential value of PET/MR in predicting pMR to nT.
- To use radiomics analysis of PET/MR data to develop a quantification clinical tools that allow a more accurate and comprehensive assessment of RC patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1.Patients with newly diagnosed RC; histopathological confirmation of adenocarcinoma of colorectal origin.
Exclusion Criteria
- •Patients younger than 18 years;
- •other known active malignancy;
- •previous chemotherapy or radiotherapy;
- •previous pelvic operation;
- •patient that no intent / not suited for neoadjuvant therapy (including metastatic disease at presentation); contraindication to intravenous contrast agents.
Outcomes
Primary Outcomes
Number of patient that shown the different between diagnostic value of single PET/MR scan in RC staging and compare it to that of MRI alone, PET/CT alone, and combined MRI and PET/CT
Time Frame: 1 year