Molecular Network Characteristics of Phlegm-heat Syndrome in Ischemic Stroke Based on Multi-omics Integrated Analysis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Omic biomarkers associated with phelm-heat syndrome in ischemic stroke
研究概览
简要总结
The molecular characteristics of ischemic stroke with phlegm-heat syndrome and candidate biomarkers were identified based on multi-omics data. The main purpose of this study is to validate the molecular characteristics and biomarkers of phlegm-heat syndrome in ischemic stroke, and to demonstrate the association of biomarkers with clinical outcomes.
详细描述
This is a cohort study in patients with ischemic stroke. The demographic characteristics, TCM syndromes, and other baseline information will be recorded. At the same time, baseline peripheral blood will be collected. These participants will be followed up to 90 days of onset, and 90-day modified Rankin scale (mRS) scores will be assessed. The collected blood samples will be tested by multi-factor detection technology for candidate biomarkers.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Acute ischemic stroke, were confirmed by magnetic resonance imaging (MRI).
- •Symptom onset within 72 hours.
- •Diagnosis of phlegm-heat syndrome or non-phlegm-heat syndrome.
- •Male or female ≥ 50 years and ≤ 80 years.
- •With written informed consent.
排除标准
- •Planned or already receiving intravenous thrombolysis or endovascular treatment.
- •Acute infectious diseases or acute exacerbations of chronic diseases within one month before enrollment.
- •Patients with previous stroke.
- •Renal or hepatic insufficiency, tumors, immune diseases, severe underlying diseases.
- •Other conditions that may affect the collection and evaluation of clinical information (e.g., severe aphasia, mental illness).
结局指标
主要结局
Omic biomarkers associated with phelm-heat syndrome in ischemic stroke
时间窗: baseline
Sensitivity, specificity, and area under the ROC curve of omic biomarkers of Phlegm-heat syndrome in ischemic stroke.
次要结局
未报告次要终点
研究者
Ying Gao
Professor
Dongzhimen Hospital, Beijing