Continued Mechanical Ventilation During CABG Operation Attenuates Systemic Immune Modulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Alteration of soluble ST2 concentration in serum
研究概览
简要总结
Cardiopulmonary bypass (CPB) is well known to induce a strong anti-inflammatory response. The investigators examined whether continued mechanical ventilation during CPB alters systemic immune activation.
详细描述
Cardiopulmonary bypass is well known to induce a strong anti-inflammatory response. Studies had been shown that the contact of blood components with artificial surfaces, the surgical trauma, endotoxemia and a reperfusion injury are in part responsible for the seen immunological affect after surgery. The purpose of this study is to test the effect of continued mechanical ventilation during surgery on a blood marker called soluble ST2 in patients sera. Soluble ST2 acts as a decoy receptor of IL-33 and has anti-inflammatory effects. Elevated soluble ST2 concentrations are reported in patients with acute myocardial infarction, sepsis, congestive heart failure and elevates soluble ST2 levels are associated with adverse outcome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Written informed consent
- •age > 40 and < 80
排除标准
- •treatment with steroids or immunomodulatory interventions during the past four weeks
- •signs of an acute infection
研究组 & 干预措施
Ventilation Group
Volume controlled ventilation was done during the whole surgery.
干预措施: Lung Ventilation (Other)
Non-ventilation Group
In the non-ventilated group lungs were collapsed after completion of CPB until after weaning from the extracorporeal circulation.
干预措施: Non-ventilated Group (Other)
结局指标
主要结局
Alteration of soluble ST2 concentration in serum
时间窗: Preoperative, postoperative, day 1, day 2, day 3, day 4, day 5 after surgery
Concentration of soluble ST2 will be assessed in the serum of patient´s preoperativem, postoperative and the following five consecutive days after surgery.
次要结局
未报告次要终点
研究者
Hendrik Jan Ankersmit
Assoc. Prof
Medical University of Vienna