The Impact of Procalcitonin on the Management of Children Aged 1 to 36 Month Presenting With a Fever Without a Source

St. Justine's Hospital1 site in 1 country384 target enrollmentNovember 2006

ConditionsProcalcitonin Fever Without Source Bacterial Infection Bacteremia

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Procalcitonin
Sponsor: St. Justine's Hospital
Enrollment: 384
Locations: 1
Primary Endpoint: Difference in prescription of antibiotics between the two groups, excluding those treated for a bacterial infection identified by the ED investigations
Status: Completed
Last Updated: 17 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Serious bacterial infections are often difficult to detect in children with fever without source. Procalcitonin is a better blood marker of infection than White blood cell count and possibly than C-reactive protein. This could lead to a reduction in antibiotic prescription. Our objective is to evaluate the impact of Procalcitonin result on antibiotic prescription in children 1 to 36 month old with fever without source and our hypothesis is that it will lower the antibiotic prescription rate

Registry

clinicaltrials.gov

Start Date

November 2006

End Date

June 2008

Last Updated

17 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

St. Justine's Hospital

Eligibility Criteria

Inclusion Criteria

•Children 1-36 months
•With rectal temperature \>38.0 C
•And no identified source of infection after history and physical examination

Exclusion Criteria

•acquired or congenital immunodeficiency

Outcomes

Primary Outcomes

Difference in prescription of antibiotics between the two groups, excluding those treated for a bacterial infection identified by the ED investigations

Secondary Outcomes

Difference in hospitalization rate between the two groups (excluding those hospitalized for an identified infection)
Procalcitonin sensitivity and specificity