NCT00185146已完成2 期
Effect of Pactimibe on the Progression of Atherosclerosis as Measured by 2-D and 3-D Carotid Ultrasound
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Efficacy of pactimibe versus placebo on the progression of atherosclerosis
研究概览
简要总结
The effect of pactimibe on the reduction of atherosclerosis in the carotid artery will be assessed using carotid ultrasound
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Increased cardiovascular risk (i.e. history of myocardial infarction, stroke, diabetes mellitus, left ventricular hypertrophy)
- •Intima-media thickness greater than or equal to 0.8 mm as measured by ultrasonography
- •Negative pregnancy test for females
排除标准
- •Whole blood donation (greater than or equal to 450 ml) during the last three months before study start
- •Unstable angina, congestive heart failure or uncontrolled hypertension
- •Renal disease including nephrectomy and/or renal transplant
- •Hepatic disease or abnormal liver function parameters
- •Drug abuse or alcohol addiction
结局指标
主要结局
Efficacy of pactimibe versus placebo on the progression of atherosclerosis
次要结局
- Safety and tolerability of pactimibe versus placebo in patients with atherosclerosis
研究者
研究点 (1)
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