Efficacy of hepatitis A vaccination in immunocompromised travelers.
- Conditions
- hepatits AvaccinationimmunosuppressionHepatitis Avaccinatieimmuunsuppressie
- Registration Number
- NL-OMON26720
- Lead Sponsor
- no sponsorfund=initiator=sponsor
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 600
Inclusion Criteria
1. All consecutive patients > 18 years of age using immunosuppressive medication who come to the travel clinics and need vaccination with hepatitis A according to LCR guidelines.
- Immunosuppressive medication is defined as use of cyclosporine A, azathioprine, cyclophosphamide, methotrexate, TNF-á blockers, prednisone use eqal to 10 mg/day or a cumulative dose of > 700 mg., tacrolimus, mycophenolate mofetil.
Exclusion Criteria
1. Allergy to the advised vaccine or its components.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Antibody titres after booster vaccination.
- Secondary Outcome Measures
Name Time Method - Antibody titres after first hepatitis A vaccination<br /><br>- Antibody production after the booster vaccination for hepatitis A<br /><br>- Determination of disease or medication related and demographic parameters that are predictive for decreased antibody production to hepatitis A vaccination.