Preoperative Serum FGF19 in the Prognosis of Biliary Atresia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Serum total bilirubin level (umol/l)
研究概览
简要总结
To investigate the role of preoperative serum FGF19 level in the prognosis of biliary atresia.
详细描述
Kasai portoenterostomy is currently one of the main treatment methods for biliary atresia, but about 30% of children still require liver transplantation even after receiving the surgery. Accurate prognosis will help select the most suitable treatment method for children, but there is currently a lack of effective preoperative predictive indicators. Serum FGF19 has recently been considered a possible preoperative predictive indicator for biliary atresia, but its predictive value has not been confirmed in a large sample and in Asian population, thus the investigators try to further explore the prognostic value of serum FGF19 in children with biliary atresia based on a large sample.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Samples diagnosed as biliary atresia in Children's Hospital of Fudan University
- •Samples with one-year follow-up records after surgery
- •Samples with a record of serum total bilirubin levels three months after surgery
- •Samples with preoperative serum left（volume > 500ul)
排除标准
- 未提供
结局指标
主要结局
Serum total bilirubin level (umol/l)
时间窗: Three months after surgery
The difference of serum total bilirubin level will be measured with ELISA( Enzyme Linked ImmunoSorbent Assay) three months after surgery
Native liver survival (%)
时间窗: One year after surgery
The difference of native liver survival will be measured according to the follow-up statue one year after surgery
次要结局
未报告次要终点