ISRCTN57761809已完成不适用
Effect of anti-tumour necrosis factor alpha (TNFa) therapy on endothelial function and other surrogate markers of cardiovascular disease in patients with rheumatoid arthritis
niversity of Dundee (UK)0 个研究点目标入组 90 人开始时间: 2008年5月9日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •1. Both males and females, 18 years old or over
- •2. Fulfil the 1987 American College of Rheumatology (ACR) classification criteria for rheumatoid arthritis
- •3. No exposure to anti-TNFa drugs in the last 3 months
- •4. Fulfil the National Institute for Clinical Excellence guidelines on the use of anti-TNFa drugs in rheumatoid arthritis* and be:
- •4.1. About to start etanercept or adalimumab (treatment group)
- •4.2. About to start methotrexate (control group)
- •* The patients in the control group must have had adequate therapeutic trial of at least one previous Disease Modifying Anti-Rheumatic Drug (DMARD) rather than two
排除标准
- •1. Previous cardiovascular or cerebrovascular event in the last 3 years
- •2. Undergoing treatment for a cardiovascular risk factor except:
- •2.1. Patients with hypertension on stable medication for the last 3 months
- •2.2. Patients with hypercholesterolaemia on stable medication for the last 3 months
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