Dietary modification for asthma control in pregnancy.

Not Applicable

Withdrawn

• Conditions: Asthma; Pregnancy; Respiratory - Asthma; Reproductive Health and Childbirth - Other reproductive health and childbirth disorders

• Registration Number: ACTRN12613000301763
• Lead Sponsor: The University of Adelaide

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-03-19
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Female
• Target Recruitment: 104

Inclusion Criteria

Pregnant women with mild or moderate/severe asthma and currently using inhaled corticosteroids, >18 years of age, and poor diet quality (less than 1 serving/day fruit and less than 2 servings/day vegetable, determined from Food Frequency Questionnaire).

Exclusion Criteria

Recent (past month) respiratory tract infection, intermittent asthma, current smoker, use of antioxidant supplements, or previous pregnancy complications including growth restriction, still birth or preterm delivery.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Asthma control score, using the validated ACQ6 questionnaire.[Assessed every 2 weeks during the 12 week study (i.e. at ~18, 20, 22, 24, 26 and 30 weeks gestation).]

Secondary Outcome Measures

Name	Time	Method
Plasma circulating concentrations of antioxidants [Measured at the beginning and at the end of the 12 week study.];Markers of oxidative stress (plasma 8-F2 isoprostanes)[Measured at the beginning and at the end of the 12 week study.];Exhaled nitric oxide (FENO: direct measure of airway inflammation)[Measured at the beginning and at the end of the 12 week study.];Time to, and number of, exacerbations: Asthma exacerbations during pregnancy (moderate and severe exacerbations) defined as events for which the participant sought medical attention (i.e. an unscheduled visit to a doctor, presentation to the emergency department room or admission to hospital, or when oral corticosteroids were used for treatment of asthma).[Measured at the beginning and at the end of the 12 week study.]