Guiding personalized treatments for Parkinson*s tremor with individual neuroimaging * an exploratory study
Phase 2
Completed
- Conditions
- Parkinson's diseasetremor10028037
- Registration Number
- NL-OMON45367
- Lead Sponsor
- eurologie
- Brief Summary
Trial is onging in other countries
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
- Idiopathic Parkinson*s disease according to UK brain bank criteria.
- Presence of a clear resting tremor of at least one arm (UPDRS tremor-score > 2).
Exclusion Criteria
- neuropsychiatric co-morbidity
- contraindications for MRI scanning (e.g. pacemaker, implanted metal parts, deep brain stimulation, claustrophobia)
- Severe head tremor or dyskinesias.
- Cognitive impairment (MMSE < 26)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>(1) Within-subjects reproducibility of tremor-related activity and connectivity<br /><br>(*tremor fingerprint*; quantified using concurrent EMG-fMRI across two<br /><br>different days); (2) Modulation of tremor-related activity and connectivity by<br /><br>TACS (comparison of the three TACS conditions); (3) Modulation of tremor by<br /><br>TACS (quantified using accelerometry), and its correlation with network<br /><br>parameters derived from the tremor circuit (i.e. thalamo-cortical<br /><br>connectivity). </p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable. See Primary outcome measure.</p><br>