The Effect of Antiemetics on Bowel Preparation Before Colonoscopy
试验速览
- 阶段
- 4 期
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Incidence of the discomforts during bowel preparation
研究概览
简要总结
Polyethylene glycol (PEG) is one of the most common laxatives used in colonoscopy. However, 5 - 15% of patients can not complete the preparation due to its poor taste and large volume. So this study is aimed to explore the effect of antiemetics on abdominal discomforts associated with PEG.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-70 years patients scheduled for colonoscopy
排除标准
- •intestinal obstruction or hemorrhage;
- •allergy to domperidone, sulpiride or PEG;
- •pregnancy or breastfeeding;
- •previous use of prokinetics within 1 month.
研究组 & 干预措施
Domperidone group
Patients in Domperidone group took 10mg of domperidone 30min before PEG.
干预措施: Domperidone (Drug)
Sulpiride group
Patients in Sulpiride group took 100mg of sulpiride 30min before PEG.
干预措施: sulpiride (Drug)
结局指标
主要结局
Incidence of the discomforts during bowel preparation
时间窗: before colonoscopy
The primary endpoint of this study was the discomforts during bowel preparation such as nausea, vomit, abdominal fullness and pain. These symptoms were assessed as none, mild, moderate and severe. Patients with mild to severe symptoms were classified as presence of discomforts.
次要结局
- The quality of bowel preparation assessed by Boston Bowel Preparation Scale(during colonoscopy)
研究者
Shengliang Chen
Deputy director of the Division of Gastroenterology and Hepatology
RenJi Hospital