Influenza-associated pulmonary aspergillosis (IAPA) in ICU patients with severe influenza: incidence and host- and pathogen related risk factors

Recruiting

• Conditions: Influenza-associated pulmonary aspergillosis; pulmonary fungal infection; 10017528

• Registration Number: NL-OMON55031
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

Patients with a PCR-positive respiratory virus panel (RVP) result for influenza
within 96 hours before or 48 hours after ICU admission.
Patients who require ICU admission for more than 24 hours for severe influenza.
Patients who have respiratory distress (respiratory rate >= 25x/minute and
paO2/fiO2 < 300 with or without bilateral infiltrates) as the main reason for
ICU admission.
Patients who do not have an EORTC host factor.
Patients who are at least 18 years of age.

Exclusion Criteria

Patients with age < 18 years as extensive sampling is required
Expected survival on ICU admission <= 48h
Patients that are being treated actively with antifungal agents for invasive
aspergillosis.
Patients or their legal representatives who did not sign the informed consent
form.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified