Pubertal Evolutionary Profile of Children Monitored for Fetal Ovarian Cyst
- Conditions
- Fetal Ovarian Cyst
- Interventions
- Other: Questionnaire
- Registration Number
- NCT04526392
- Lead Sponsor
- University Hospital, Toulouse
- Brief Summary
This study is based on pubertal surveillance of fetal ovarian cysts (KOF). Fetal ovarian cysts (KOF) detected during fetal ultrasound examinations occur during the 3rd trimester of pregnancy and are of unknown cause.
- Detailed Description
These cysts are functional in the vast majority of cases and are therefore likely to disappear spontaneously, but they may become complicated before regressing. Apart from complication, the natural evolution of these cysts, which are said to be "simple" because they are liquid on ultrasound, is towards regression in the first months of neo-natal life.
Surveillance during the 1st year of life showed that simple cysts regressed during the 1st trimester. In the case of complicated cysts, oophorectomy was necessary in 9 cases. In the 1-year follow-up, the ovarian recovery rate was significantly different depending on the appearance of the cyst (p\<0.0001); 60 ovaries out of 89 homolateral to the cyst were follicular, of which 48/49 (98%) were carriers of fluid cysts and 12/40 (30%) were initially heterogeneous. The origin of these cysts is unknown, the ovary is again physiologically stimulated during the onset of puberty. No series in the literature gives the long-term ovarian prognosis for these patients. We wish to evaluate the pubertal evolutionary profile of patients followed at the University Hospital for KOF. The data collected concerning puberty (age of menses) will be examined in relation to the age of menses in the siblings and in the mother, as well as to the data in the literature on the age of the first menses in France.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 83
- Patients at least 8 years of age at the time of inclusion.
- Patients being followed for fetal ovarian cyst.
- Minor patients of whom at least one of the two holders of parental authority has given his or her non-opposition.
- Patients covered by a social security scheme.
- Patients less than 8 years of age at the time of inclusion
- Ovarian cysts outside the neonatal period
- Refusal to participate.
- Opposition to disclosure of neonatal data.
- Pregnant or nursing patient.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Questionnaire Questionnaire Patients will choose how they wish to complete the Pubertal Course Questionnaire: electronically (web link), on paper, by telephone, or face-to-face at a follow-up consultation.
- Primary Outcome Measures
Name Time Method Age of onset of first menstruation Day 1 Age of onset of first menstruation defined with one decimal place (year and month).
- Secondary Outcome Measures
Name Time Method Hormonal levels - AMH Day 1 AMH levels
Hormonal levels - LH Day 1 Luteinizing hormone (LH) levels
Hormonal levels - FSH Day 1 follicle stimulating hormone (FSH) levels
Hormonal levels - estradiol Day 1 estradiol levels
rate of ovarian cyst recurrence Day 1 Ovarian cyst recurrence rate
Presence or not of follicles Day 1 Presence or not of follicles on both ovaries.
Average age of maternal and sister rules Day 1 Average age of maternal and sister menstruation.
Ovarian volumes Day 1 Homo and contralateral ovarian volumes at the cyst.
first menstruation description - age of breast onset Day 1 Age of breast onset
first menstruation description - cycle disorder Day 1 rate of patients with cycle disorder
first menstruation description - cycle length Day 1 cycle length in the last three months
first menstruation description menorrhagia Day 1 menorrhagia
percentage of hyperandrogenism Day 1 Percentage of girls with clinical signs of hyperandrogenism or elevated testosterone levels.
first menstruation description dysmenorrhoea. Day 1 dysmenorrhoea.
Trial Locations
- Locations (1)
Toulouse University Hospital
🇫🇷Toulouse, France