To explore the essence of DOR kidney-yang deficiency syndrome and the intervention mechanism of Yangluanfang decoction based on follicular fluid metabolomics

Phase 1

Recruiting

• Conditions: Decreased ovarian reserve

• Registration Number: ITMCTR2000004109
• Lead Sponsor: Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

The inclusion criteria of the observation group were as follows:
1. Married female patients aged 20 ~ 40 years old, Those with fertility requirements;
2. Meet the diagnostic criteria for infertility due to decreased ovarian reserve function, and TCM syndrome differentiation belongs to kidney-yang deficiency;
3. No obvious abnormality was found in the sperm examination of the male;
4. Volunteer to participate in this study and sign the informed consent, can actively cooperate with the follow-up, complete the clinical observer.
The inclusion criteria of the control group were as follows:
1. Married female patients aged 20 ~ 40 years old, those with fertility requirements;
2. In line with the diagnostic criteria of tubal obstructive infertility;
3. In line with the standard of normal ovarian reserve function;
4. No obvious abnormalities were found in the sperm examination of the man;
5. Voluntarily participate in this study and sign the informed consent, actively cooperate with the follow-up visits and complete the clinical observation.

Exclusion Criteria

1. Those with previous mental illness or allergic constitution;
2. Previous history of various malignant tumors, cardiovascular and cerebrovascular disease, abnormal liver and kidney function, or hematopoietic system and other serious primary diseases;
3. Men with abnormal reproductive functions;
4. Women with polycystic ovary syndrome, immune factors, endometriosis and other infertility factors;
5. Organic lesions or congenital physiological defects or malformations of the reproductive system;
6. Long-term application of exogenous hormone therapy for patients.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum estradiol;Serum follicle-stimulating hormone;Serum anti-Mullerian hormone;Sinus follicle count;Serum progesterone;Serum luteinizing hormone;

Secondary Outcome Measures

Name	Time	Method
Grade III oocyte rate;High quality embryo rate;Syndrome integral of kidney-Yang deficiency;Fertilization rate;The oocyte count was obtained;