Histomorphological Study of the Intraepidermal Nerve Fiber Density (IENFD) and Composition of the Dermal Inflammatory Infiltrate in Itching Dermatoses, Itching Systemic Diseases and Itch Without Inflammatory Skin Lesions

• Conditions: L28.1; L29.9; Prurigo nodularis; Pruritus, unspecified

• Registration Number: DRKS00008006
• Lead Sponsor: Kompetenzzentrum chronischer Pruritus (KCP) und Klinik für Hautkrankheiten Universitätsklinikum Münster

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2012-10-01
• Study Start: 2015-05-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 265

Inclusion Criteria

Patients with atopic dermatitis, prurigo nodularis, nephrogenic Pruritus, cholestatic Pruritus, diabetogenic pruritus, brachioradial pruritus, small fiber neuropathy, pruritus on non-inflammatory skin and normal skin

Exclusion Criteria

pregnancy, breastfeeding, wound healing disorders or tendency to keloid

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determination of intraepidermal nerve fiber density and inflammatory infiltrate in atopic dermatitis, prurigo nodularis, nephrogenic Pruritus, cholestatic Pruritus, diabetogenic pruritus, brachioradial pruritus, small fiber neuropathy, pruritus on non-inflammatory skin and normal skin

Secondary Outcome Measures

Name	Time	Method
Characterisation of the inflammatory infiltrate in prurigo nodularis patients via immunohistochemiistry and FACS-analysis<br>Comparison of the intraepidermal nerve fiber density in lesional, non-lesional, interlesional and recovered skin in prurigo nodularis.