Comparison of effects of sugammadex in recommended dose and fixed dose on reversal of moderate neuromuscular blocking and recovery profile in patients under general anaesthesia.

This prospective, double blinded, randomized controlled trial compares the effects and recovery patterns of a fixed dose 200mg of sugammadex versus the recommended 2mg/kg dose for reversing moderate neuromuscular blockade in adults undergoing general anesthesia for elective surgeries expected to last over 120 minutes. The study aims to enroll 40 consented patients who are fulfilling inclusion criteria and assessed for exclusion criteria. Participants will be randomly allocated with the help of computer generated randomisation to either Group R (2mg/kg sugammadex) or Group F (200mg sugammadex), both administered as slow intravenous infusion in 100ml normal saline. Then time taken to achieve a normalized Train-of-Four (TOF) ratio greater than or equal to 0.9 in the two dosing strategies. Simultaneously the time from sugammadex administration to spontaneous respiration, response to verbal commands, adequate motor control, extubation and total recovery time is also measured alongside monitoring and managing adverse events such as bradycardia or anaphylaxis. Comprehensive intraoperative monitoring including ECG, NIBP, SpO2, EtCO2, Temperature, Heart Rate, Neuromuscular Function via TOF and bispectral index will be employed. All the data are recorded every 5 minutes intraoperatively and every 15 seconds after sugammadex administration.