Vascular changes in retina in amblyopic eyes verse in healthy eyes
- Conditions
- Visual disturbances and blindness, (2) ICD-10 Condition: H53-H54||Visual disturbances and blindness,
- Registration Number
- CTRI/2021/11/038090
- Lead Sponsor
- Varsha Negi
- Brief Summary
The study will be conducted in children with amblyopia attending the outpatientdepartment and Paediatric Ophthalmology Clinic in Guru Nanak Eye Centre.A total of 60 eyes will be included in the study.They will be divided into threegroups (20 eyes in each group). Group1- Amblyopic Eyes,Group2- Fellow Eyes, Group3- Control Eyes.The Study Time is one year.UsingOCTA (RS-3000 LITE advanced (NIDEK)following parameters will be evaluated-
1. Foveal Avascular Zone Measurements (mm2)
2.Macular Vessel density percentage of SCP scan
3.Macular Vessel density percentage of DCP scan
Using OCT(Revo 60 Optipol) following parameters will be evaluated-
1.CentralMacular Thickness (µm)
2. Peripapillary Retinal Nerve Fibre Layerthickness(µm)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
1.Patients in the age group of 6 to18 years with strabismic and anisometropic amblyopia (difference of at least 2 lines in BCVA between 2 eyes) 2.Age and Gender matched patients referred to OPD for routine eye examination will be recruited as control eyes.
- 1.Poor quality scans and un co-operative child.
- 2.Children with spherical refractive errors of +/- 5.00 diopters(D) or greater and cylindrical refractive errors of 3.00 diopters(D) or greater.
- 3.Children with poor fixation, nystagmus, eccentric fixation.
- 4.Ocular diseases viz.
- cataract, corneal opacities, uveitis, retinal pathology 5.History of intraocular surgery 6.History of any systemic condition that could alter the retinal microvasculature.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Foveal Avascular Zone Measurements (mm square) Baseline 2.Macular Vessel density percentage of SCP scan Baseline 3.Macular Vessel density percentage of DCP scan Baseline
- Secondary Outcome Measures
Name Time Method 1.Central Macular thickness (µm) 2.Peripapillary Retinal nerve fiber layer thickness (µm)
Trial Locations
- Locations (1)
Guru Nanak eye Center
🇮🇳Delhi, DELHI, India
Guru Nanak eye Center🇮🇳Delhi, DELHI, IndiaVarsha NegiPrincipal investigator9582012577varshanegi96@gmail.com