EFFECT OF IRRIGATION WITH OZONIZED WATER DURING ULTRASONIC SCALING IN MANAGEMENT OF PERIODONTITIS- A RANDOMISED CONTROLLED CLINICAL TRIAL
Trial Snapshot
- Phase
- Phase 1
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Results of evaluation of clinical parameters
Study Overview
Brief Summary
Ozone has been shown topossess unique properties and has potential applications to the clinicalpractice of dentistry and medicine. Ozone oxidizes biomolecules, disruptsmicrobial cell structures and metabolism. Ozone disrupts microbial cell walls inseconds, leading to immediate cell lysis. An ozone application of 10 – 20 secondhas been reported to eliminate more than 99% of the microorganisms found in thedental caries .Ozone has been applied for treatment of earlycarious lesions, sterilization of cavities, root canals, enhancing epithelial woundhealing such as ulcerations and herpetic lesions
Periodontitisis a chronic multifactorial inflammatory disease of microbial origin. Thebeneficial properties of ozone such as antimicrobial (bactericidal, viricidal,and fungicidal) immunostimulating, immune modulatory and anti-inflammatorymakes it an excellent choice for treatment of periodontitis
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Not Applicable
Eligibility Criteria
- Ages
- 20.00 Year(s) to 75.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients with Generalized Stage III periodontitis ( diagnosed according to 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions) Patients with minimum of 20 remaining teeth Subjects with Probing Pocket Depth (PPD) greater than or equal to 5mm.
- •Subjects with gingival index score greater than or equal to
- •Subjects who have not received periodontal therapy within the last 6 months.
- •Those willing to participate in the study.
Exclusion Criteria
- •Patients with systemic diseases which contraindicate periodontal surgical procedures Patients who have taken antibiotics or anti-inflammatory drugs for the past 3 months Pregnant and lactating females.
- •Immunocompromised patients Patients who are undergoing orthodontic treatment.
Outcomes
Primary Outcomes
Results of evaluation of clinical parameters
Time Frame: 20 minutes
Secondary Outcomes
- Results of biochemical analysis of saliva and indices like Plaque Index((Turesky- Gilmore-Glickman modification of Quigley –Hein), Gingival Index)