EFFECT OF IRRIGATION WITH OZONIZED WATER DURING ULTRASONIC SCALING IN MANAGEMENT OF PERIODONTITIS- A RANDOMISED CONTROLLED CLINICAL TRIAL
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Results of evaluation of clinical parameters
研究概览
简要总结
Ozone has been shown topossess unique properties and has potential applications to the clinicalpractice of dentistry and medicine. Ozone oxidizes biomolecules, disruptsmicrobial cell structures and metabolism. Ozone disrupts microbial cell walls inseconds, leading to immediate cell lysis. An ozone application of 10 – 20 secondhas been reported to eliminate more than 99% of the microorganisms found in thedental caries .Ozone has been applied for treatment of earlycarious lesions, sterilization of cavities, root canals, enhancing epithelial woundhealing such as ulcerations and herpetic lesions
Periodontitisis a chronic multifactorial inflammatory disease of microbial origin. Thebeneficial properties of ozone such as antimicrobial (bactericidal, viricidal,and fungicidal) immunostimulating, immune modulatory and anti-inflammatorymakes it an excellent choice for treatment of periodontitis
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 20.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with Generalized Stage III periodontitis ( diagnosed according to 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions) Patients with minimum of 20 remaining teeth Subjects with Probing Pocket Depth (PPD) greater than or equal to 5mm.
- •Subjects with gingival index score greater than or equal to
- •Subjects who have not received periodontal therapy within the last 6 months.
- •Those willing to participate in the study.
排除标准
- •Patients with systemic diseases which contraindicate periodontal surgical procedures Patients who have taken antibiotics or anti-inflammatory drugs for the past 3 months Pregnant and lactating females.
- •Immunocompromised patients Patients who are undergoing orthodontic treatment.
结局指标
主要结局
Results of evaluation of clinical parameters
时间窗: 20 minutes
次要结局
- Results of biochemical analysis of saliva and indices like Plaque Index((Turesky- Gilmore-Glickman modification of Quigley –Hein), Gingival Index)