Dual Energy CT Urography Using 50% Reduction in Iodinated Contrast: Feasibility, Image Quality, and Radiation Dose Reduction With Virtual Unenhanced Images.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Washington
- Enrollment
- 62
- Locations
- 2
- Primary Endpoint
- Diagnostic ability determined by image quality (subjective and objective evaluation of vessel attenuation and depiction, image noise, image quality and information from virtual non-contrast
Study Overview
Brief Summary
The goal of this study is to validate that Dual Energy CT (DECT) urography when performed with a 50% reduction in iodinated contrast dose results in a CT exam with equal or better image quality and equal or better diagnostic capability compared to traditional Single Energy CT (SECT) performed with a standard contrast dose.
Detailed Description
The investigators hypothesize that DECT urography performed with a 50% iodine dose reduction is equivalent to SECT urography performed with a full iodine dose for:
- Enhancement of the aorta, renal arteries, and renal veins
- Enhancement of the renal cortex
- Enhancement of the renal pelvis, ureters, and bladder
- Subjective evaluation of image quality
- Objective evaluation of image quality
In addition, the investigators hypothesize that DECT virtual non-contrast images using material suppression from the same low iodine CT exam results in equivalent diagnostic information compared to SECT true non-contrast images obtained in the same patient during the same exam. If the true non-contrast images could be replaced by the virtual non-contrast images without loss of information, there is potential for DECT to both significantly lower radiation dose as well as significantly decreasing iodine dose.
The investigators designed this research protocol to prospectively test these hypotheses in a population scanned with a 50% reduced iodine DECT urography protocol compared to a control population scanned with a standard iodine dose clinical SECT urography protocol.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 50 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Outpatient scheduled to have a CT urography at the site
Exclusion Criteria
- •Severe allergy to iodine containing contrast
- •Pregnancy (which is very unlikely for those over 50)
- •Body mass index (BMI) over 35 kg/m2
- •Inability to provide informed consent
- •Inpatient
Arms & Interventions
Reduced contrast DECT scan
Reduced Contrast Dual Energy CT
Intervention: Reduced contrast DECT scan (Other)
Reduced contrast DECT scan
Reduced Contrast Dual Energy CT
Intervention: Standard contrast SECT scan (Other)
Outcomes
Primary Outcomes
Diagnostic ability determined by image quality (subjective and objective evaluation of vessel attenuation and depiction, image noise, image quality and information from virtual non-contrast
Time Frame: Up to 24 months
Secondary Outcomes
No secondary outcomes reported
Investigators
William Shuman
Professor and Vice Chair of Radiology
University of Washington