Effect of dietary nitrate supplementation on brain blood vessel health

Not Applicable

Completed

• Conditions: Transient ischaemic attack; Stroke - Ischaemic

• Registration Number: ACTRN12616000086460
• Lead Sponsor: Mickey Fan

Brief Summary

We found dietary nitrate supplementation reduced blood pressure and brain blood flow fluctuations and improved the relationship between blood pressure and brain blood flow in transient ischemic attack patients. Meanwhile, dietary nitrate had no effects on the brain blood vessels’ response to CO2. We attribute the improved brain blood flow stability to the improved myogenic control of blood pressure with dietary nitrate. Our findings indicate that dietary nitrate could be an effective strategy for stabilizing blood pressure and brain blood flow following transient ischemic attack.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-01-27
• Study Completion: 2018-06-07
• Last Update Posted: 5 January 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Patient group
1) Those individuals aged 40-85 diagnosed as high risk TIA (with ABCD2 score greater than or equal to 4), after review by a specialist stroke physician
2) Those individuals living within Wellington City and the Greater Wellington region
Healthy group
1) Healthy individuals (age 20-85 years) of both sex, specifically:
2) Free of history of long-term disease
3) Not currently taking any medication that may influence measures in this study.
4) Those individuals living within Wellington City and the Greater Wellington region

Exclusion Criteria

Patient group
1) Those individuals requiring supplementary oxygen
2) Individuals with allergy to nitrates
3) Unstable cardiac conditions or angina
4) Uncontrolled diabetes mellitus
5) Major medical conditions
6) Significant cognitive impairment
7) Immobility

Healthy group
1) Very high (greater than 140/90) or very low (lower than 100/60) resting blood pressure
2) Previous history of stroke, brain surgery, or severe head trauma
3) Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified