Serum Oncostatin M in Ulcerative Colitis Patients and Its Relation to Severity and Acute Exacerbation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 99
- 主要终点
- Identify if oncostatin M is a good marker
研究概览
简要总结
Ulcerative colitis (UC) is a refractory disease characterized by symptoms such as diarrhea, bloody stools, and abdominal pain with repeated relapses and remissions.
详细描述
Evaluation of UC activity is important, and endoscopic evaluations of mucosal inflammation can facilitate subsequent prognostication. On the basis of these considerations, achievement of mucosal healing is important in inflammatory bowel disease (IBD), and evaluation of IBD using endoscopy is extremely important. However, endoscopic examinations are associated with problems such as physical burden to the patient, cost, and risk of complications.
Thus, to avoid the need for frequent endoscopy, noninvasive biomarkers that accurately reflect the endoscopic activity of UC have emerged, and fecal calprotectin (FC) and the fecal immunochemical occult blood test (FIT) are being widely used in clinical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All patients aged >18 years and <80 years, of both gender who diagnosed to have UC and given the consent for participation in the study
排除标准
- •1- Any patient with systemic inflammation as Bronchial asthma. 2- History of cancer or tumor. 3- Autoimmune disease such as rheumatoid arthritis and systemic lupus erythematous
研究组 & 干预措施
Control
45 apparently healthy subjects as controls who were not UC
干预措施: Oncostatin M (Diagnostic Test)
Ulcerative colitis Patients
45 Patients with UC. The diagnosis of UC will be based on endoscopic finding and histopathological finding
干预措施: Oncostatin M (Diagnostic Test)
结局指标
主要结局
Identify if oncostatin M is a good marker
时间窗: 6 months
Diagnosis of Ulcerative colitis and follow up
次要结局
未报告次要终点
研究者
mohamed gamal mohamed abdel aleem
Doctor
Beni-Suef University