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Physical Activity Training Program for Patients With Alzheimer's Dementia

Not Applicable
Completed
Conditions
Dementia
Registration Number
NCT02196545
Lead Sponsor
Technische Universität Dresden
Brief Summary

The purpose of this study is to determine if a home based physical activity training program for patients with Alzheimer's dementia has effects on clinical and neurobiological parameters.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
30
Inclusion Criteria
  • age >55 years
  • German is the dominant language (necessary for neuropsychological testing)
  • minimum of 8 years formal school education
  • caregiver (e.g. spouse) living at home with participant
  • physical examination does not reveal contraindications to physical activity
  • stable dose of pharmacological dementia treatment according to German guidelines (DGPPN) with acetylcholinesterase inhibitor or memantin or combination for at least 6 months
  • no other medication that could influence cognitive functioning (e.g. benzodiazepines, sleep aids, neuroleptics)
Exclusion Criteria
  • history of neurological or psychiatric disease other than AD
  • history of substance abuse disorder
  • history of electroconvulsive therapy (ECT) during the last 6 months
  • structural brain deficits diagnosed in the MRI scan, also without clinical relevance (incidental finding)
  • pacemaker, artificial heart valve, insulin pump or other medical implants
  • average steps/day are above 10.000 steps/day

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
activities of daily livingchange from baseline after 12 weeks

Alzheimer's Disease Cooperative Study/Activities of Daily Living (ADCS/ADL)

Secondary Outcome Measures
NameTimeMethod
caregiver burdenchange from baseline after 12 weeks and 24 weeks

Neuropsychiatric inventory (NPI) total burden score

behavioral symptoms of dementiachange from baseline after 12 weeks and 24 weeks

Neuropsychiatric Inventory (NPI) total score

Reaction time, hand-eye quickness and attentionchange from baseline after 12 weeks and 24 weeks

Ruler Drop Test

activities of daily livingchange from baseline after 24 weeks

Alzheimer's Disease Cooperative Study/Activities of Daily Living (ADCS/ADL)

executive function and language abilitychange from baseline after 12 weeks and 24 weeks

semantic and phonemic word fluency

cognitionchange from baseline after 12 weeks and 24 weeks

Mini Mental Status Examination (MMSE)

Trial Locations

Locations (1)

Technische Universität Dresden

🇩🇪

Dresden, Saxony, Germany

Technische Universität Dresden
🇩🇪Dresden, Saxony, Germany

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