Study of Oral Venetoclax Tablets to Evaluate Adverse Events and Change in Disease Activity in Participants of Any Age With Acute Myeloid Leukemia

Completed

• Conditions: Acute Myeloid Leukemia (AML)

• Registration Number: NCT04813263
• Lead Sponsor: AbbVie

Brief Summary

Acute Myeloid Leukemia (AML) is an aggressive and rare cancer of myeloid cells (a white blood cell responsible for fighting infections) and is the most common acute leukemia in adults. This study will assess how safe and effective oral venetoclax is in participants with AML. Adverse events and change in disease activity will be monitored under routine clinical practice.

Venetoclax is an approved drug to treat Acute Myeloid Leukemia (AML). Around 400 participants of any age who are treated with oral venetoclax tablets for AML in accordance with the approved label will be enrolled in the study across Japan.

Participants will be followed up to 52 weeks following the first dose of oral venetoclax tablets.

There is expected to be no additional burden for participants in this study. Data will be collected by information provided by participating physicians based on routine medical records.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-03-22
• Study First Submitted QC: 2021-03-22
• Study First Posted: 2021-03-24
• Study Start: 2021-05-28
• Primary Completion: 2024-04-30
• Study Completion: 2024-04-30
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-24
• Last Update Posted: 2025-04-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 424

Inclusion Criteria

• All participants who are administered venetoclax for treatment of AML.

Exclusion Criteria

None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage of Participants With ≥ Grade 3 Neutropenia of Venetoclax Regimens With Unfit Acute Myeloid Leukemia (AML)	Up to 52 weeks.	Percentage of participants with a high grade (≥ Grade 3) protocol specified neutropenia during and after treatment with venetoclax.

Secondary Outcome Measures

Name	Time	Method
Median Overall Survival	Up to 52 weeks	Time from the date of first oral Venetoclax intake to the date of death from any cause.
Percentage of Participants With Tumor Lysis Syndrome (TLS)	Up to 52 weeks	Percentage of participants with protocol specified TLS during and after treatment with venetoclax.
Percentage of Participants With AE/ADR When Used Concomitantly With CYP3A Inhibitors or Growth Colony Stimulating Factor (G-CSF)	Up to 52 weeks	An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. The investigator assessed the relationship of each event to the use of study drug as either definitely related, probably related, possibly related or unrelated.
Percentage of Participants With Composite Complete Remission Rate (CR + CRi)	Up to 52 weeks	Composite Complete remission (CRc) is defined as Complete Remission (CR) + CRi (CR with incomplete blood count recovery) based on protocol criteria.
Percentage of Participants With Febrile Neutropenia and Thrombocytopenia	Up to 52 weeks	Percentage of participants with protocol specified febrile neutropenia and thrombocytopenia during and after treatment with venetoclax.
Percentage of Participants Reported Adverse Events (AE)/Adverse Drug Reaction (ADR)	Up to 52 weeks	An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. The investigator assessed the relationship of each event to the use of study drug as either definitely related, probably related, possibly related or unrelated.
Median Time to Best Response	Up to 52 weeks.	Time to Best Response is measured as the time in months from the first dose of study treatment to the date of first documented documentation of a confirmed response of partial response (PR) or better.
Median Treatment Duration	Up to 52 weeks	Median time for duration of oral venetoclax treatment in participants with Acute Myeloid Leukemia.
Median Duration of Composite Complete Remission	Up to 52 weeks	Time from the date of first oral Venetoclax intake and the date of the assessment having documented Complete Remission with incomplete Hematologic recovery (CRi).
Percentage of Participants Reported >= Grade 3 Adverse Events (AE)/Adverse Drug Reactions (ADR)	Up to 52 weeks	Grade 3 and above AE/ADR are serious adverse event (SAE) that results in death, is life-threatening, requires or prolongs hospitalization, results in a congenital anomaly, persistent or significant disability/incapacity or is an important medical event that, based on medical judgment, may jeopardize the subject and may require medical or surgical intervention to prevent any of the outcomes listed above.

Trial Locations

Locations (281)

Odate Municipal General Hospital /ID# 258238; 🇯🇵 Odate-shi, Akita, Japan

Yokohama City University Medical Center /ID# 248777; 🇯🇵 Yokohama shi, Kanagawa, Japan

Kyoto University Hospital /ID# 244844; 🇯🇵 Kyoto-shi, Kyoto, Japan

Sumitomo Hospital /ID# 243774; 🇯🇵 Kita-ku, Osaka, Japan

Toyohashi Municipal Hospital /ID# 243784; 🇯🇵 Toyohashi-shi, Aichi, Japan

Kameda General Hospital /ID# 241877; 🇯🇵 Kamogawa-shi, Chiba, Japan

Chiba West General Hospital /ID# 262918; 🇯🇵 Matsudo-shi, Chiba, Japan

Tsudanuma Central General Hospital /ID# 245890; 🇯🇵 Narashino-shi, Chiba, Japan

National Hospital Organization Kyushu Medical Center /ID# 242026; 🇯🇵 Fukuoka shi, Fukuoka, Japan

Fukuoka Wajiro Hospital /ID# 238755; 🇯🇵 Fukuoka-shi, Fukuoka, Japan

Toyokawa City Hospital /ID# 242707; 🇯🇵 Toyokawa-shi, Aichi, Japan

Duplicate_Chiba Cancer Center /ID# 248122; 🇯🇵 Chiba-shi, Chiba, Japan

KK Clinic Ichihara /ID# 250859; 🇯🇵 Ichihara City, Chiba, Japan

Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital /ID# 242173; 🇯🇵 Nagoya-shi, Aichi, Japan

Fukuiken Saiseikai Hospital /ID# 245062; 🇯🇵 Fukui-shi, Fukui, Japan

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital /ID# 240880; 🇯🇵 Hiroshima-shi, Hiroshima, Japan

Hokkaido University Hospital /ID# 244223; 🇯🇵 Sapporo-shi, Hokkaido, Japan

Tenshi Hospital /ID# 243051; 🇯🇵 Sapporo, Hokkaido, Japan

Hyogo Medical University Hospital /ID# 240569; 🇯🇵 Nishinomiya-shi, Hyogo, Japan

Hyogo Prefectural Tamba Medical Center /ID# 240884; 🇯🇵 Tamba-shi, Hyogo, Japan

Hyogo College of Medicine Sasayama Medical Center /ID# 240888; 🇯🇵 Tanbasasayama-shi, Hyogo, Japan

JA Toride Medical Center /ID# 240573; 🇯🇵 Toride-shi, Ibaraki, Japan

Toyota Memorial Hospital /ID# 242175; 🇯🇵 Toyota-shi, Aichi, Japan

Asahi General Hospital /ID# 233889; 🇯🇵 Asahi-shi, Chiba, Japan

Chiba Aoba Municipal Hospital /ID# 240565; 🇯🇵 Chiba-shi, Chiba, Japan

Tokyo Dental College Ichikawa General Hospital /ID# 262626; 🇯🇵 Ichikawa-shi, Chiba, Japan

Nippon Medical Chiba Hokusoh Hospital /ID# 250297; 🇯🇵 Inzai-shi, Chiba, Japan

Chibaken Saiseikai Narashino Hospital /ID# 254491; 🇯🇵 Narshino-shi, Chiba, Japan

Edogawa Hospital /ID# 239352; 🇯🇵 Edogawa-ku, Tokyo, Japan

Anjou Kousei Hospital /ID# 244213; 🇯🇵 Anjo-shi, Aichi, Japan

Nagoya City University Hospital /ID# 256177; 🇯🇵 Nagoya shi, Aichi, Japan

Showa General Hospital /ID# 258235; 🇯🇵 Kodaira, Tokyo, Japan

Aichi Cancer Center Hospital /ID# 243785; 🇯🇵 Nagoya-shi, Aichi, Japan

Nagoya University Hospital /ID# 246009; 🇯🇵 Nagoya-shi, Aichi, Japan

Akita city Hospital /ID# 240008; 🇯🇵 Akita-shi, Akita, Japan

Aomori Prefectural Central Hospital /ID# 249442; 🇯🇵 Aomori-shi, Aomori, Japan

National Hospital Organization Hirosaki General Medical Center /ID# 246008; 🇯🇵 Hirosaki-shi, Aomori, Japan

Chiba Rosai Hospital /ID# 238767; 🇯🇵 Ichihara-shi, Chiba, Japan

Fukuoka University Hospital /ID# 244214; 🇯🇵 Fukuoka-shi, Fukuoka, Japan

Nagata Hospital /ID# 256180; 🇯🇵 Yanagawa-shi, Fukuoka, Japan

Homecareclinicn-Consept /Id# 239377; 🇯🇵 Sapporo, Hokkaido, Japan

Itami City Hospital /ID# 233888; 🇯🇵 Itami-shi, Hyogo, Japan

Kobe City Medical Center General Hospital /ID# 246010; 🇯🇵 Kobe-shi, Hyogo, Japan

Shonan Tobu Sogo Hospital /ID# 241913; 🇯🇵 CHIGASAKI-shi, Kanagawa, Japan

Teikyo University Mizonokuchi Hospital /ID# 244842; 🇯🇵 Kawasaki, Kanagawa, Japan

Kanagawa Cancer Center /ID# 246822; 🇯🇵 Yokohama-shi, Kanagawa, Japan

Kumamoto University Hospital /ID# 239720; 🇯🇵 Kumamoto shi, Kumamoto, Japan

Kumamoto City Hospital /ID# 254494; 🇯🇵 Kumamoto-shi,Kumamoto, Kumamoto, Japan

Nara Prefecture General Medical Center /ID# 254492; 🇯🇵 Nara-shi, Nara, Japan

Tenri Hospital /ID# 250855; 🇯🇵 Tenri-shi, Nara, Japan

Kindai University Hospital /ID# 250851; 🇯🇵 Osakasayama-shi, Osaka, Japan

Shimane University Hospital /ID# 255194; 🇯🇵 Izumo-shi, Shimane, Japan

The Jikei University Kashiwa Hospital /ID# 259510; 🇯🇵 Kashiwa-shi, Chiba, Japan

Kimitsu Chuo Hospital /ID# 248776; 🇯🇵 Kisarazu-shi, Chiba, Japan

IUHW Narita Hospital /ID# 240574; 🇯🇵 Narita-shi, Chiba, Japan

Toho University Sakura Medical Center /ID# 252187; 🇯🇵 Sakura-shi, Chiba, Japan

Watanabe Hospital /ID# 254476; 🇯🇵 Matsuyama City, Ehime, Japan

Ehime Prefectural Central Hospital /ID# 261348; 🇯🇵 Matsuyama-shi, Ehime, Japan

Matsuyama Shimin Hospital /ID# 243050; 🇯🇵 Matsuyama-shi, Ehime, Japan

National Hospital Organization Shikoku Cancer Center /ID# 242171; 🇯🇵 Matsuyama-shi, Ehime, Japan

Ehime University Hospital /ID# 244207; 🇯🇵 Toon-shi, Ehime, Japan

Murakami Karindoh Hospital /ID# 256179; 🇯🇵 Fukuoka-shi, Fukuoka, Japan

Shinkoga Hospital /ID# 248786; 🇯🇵 Kurume City, Fukuoka, Japan

Fukushima Minami Cardiovascular Hospital /ID# 252216; 🇯🇵 Fukushima-shi, Fukushima, Japan

Ogaki Municipal Hospital /ID# 239353; 🇯🇵 Ogaki-shi, Gifu, Japan

Kitami Red Cross Hospital /ID# 251065; 🇯🇵 Kitami-shi, Hokkaido, Japan

Sapporo Hokushin Hospital /ID# 241878; 🇯🇵 Sapporo-shi, Hokkaido, Japan

Iwate Medical University Hospital /ID# 251009; 🇯🇵 Shiwa-gun, Iwate, Japan

Japan Organization of Occupational Health and Society Kanto Rosai Hospital /ID# 255195; 🇯🇵 Kawasaki-shi, Kanagawa, Japan

Saiseikai Yokohamashi Nanbu Hospital /ID# 247955; 🇯🇵 Yokohama-shi, Kanagawa, Japan

Nagasaki University Hospital /ID# 245028; 🇯🇵 Nagasaki-shi, Nagasaki, Japan

Nara Hospital Kinki University Faculty of Medicine, /ID# 250295; 🇯🇵 Ikoma-shi, Nara, Japan

Nara Medical University Hospital /ID# 251726; 🇯🇵 Kashihara-shi, Nara, Japan

Oita Prefectural Hospital /ID# 243786; 🇯🇵 Oita-shi, Oita, Japan

Naha City Hospital /ID# 242027; 🇯🇵 Naha, Okinawa, Japan

Kyushu University Hospital /ID# 248781; 🇯🇵 Fukuoka-shi, Fukuoka, Japan

Japanese Red Cross Fukuoka Hospital /ID# 241181; 🇯🇵 Fukuoka-shi, Fukuoka, Japan

National Hospital Organization Kyushu Cancer Center /ID# 244217; 🇯🇵 Fukuoka-shi, Fukuoka, Japan

Aso Iizuka Hospital /ID# 266806; 🇯🇵 Iizuka, Fukuoka, Japan

Wakamatsu Hospital /ID# 251728; 🇯🇵 Kitakyusyu-shi, Fukuoka, Japan

Steel Memorial Muroran Hospita /ID# 231383; 🇯🇵 Muroran-shi, Hokkaido, Japan

Obihiro kosei Hospital /ID# 252218; 🇯🇵 Obihiro-shi, Hokkaido, Japan

Sapporo Hokuyu Hospital /ID# 250856; 🇯🇵 Sapporo-shi, Hokkaido, Japan

Hokkaido Cancer Center /ID# 249441; 🇯🇵 Sapporo-shi, Hokkaido, Japan

Sapporo Medical University Hospital /ID# 252217; 🇯🇵 Sapporo-shi, Hokkaido, Japan

Sapporo Kiyota Hospital /ID# 231385; 🇯🇵 札幌市, Hokkaido, Japan

Hyogo Prefectural Amagasaki General Medical Center /ID# 239355; 🇯🇵 Amagasaki-shi, Hyogo, Japan

Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 249446; 🇯🇵 Sapporo-shi, Hokkaido, Japan

Hyogo Prefectural Kobe Children's Hospital /ID# 245817; 🇯🇵 Kobe-shi, Hyogo, Japan

Hyogo?Prefectural?Nishinomiya Hospital /ID# 239354; 🇯🇵 Nishinomiya-shi, Hyogo, Japan

National Hospital Organization Mito Medical Center /ID# 239719; 🇯🇵 Higashi Ibaraki-gun, Ibaraki, Japan

Medical Corporation Seijinkai Ikeda Hospital /ID# 242174; 🇯🇵 Kanoya-shi, Kagoshima, Japan

Miyazaki Prefectural Miyazaki Hospital /ID# 251730; 🇯🇵 Miyazaki-shi, Miyazaki, Japan

Koga General Hospital /ID# 248120; 🇯🇵 Miyazaki-shi, Miyazaki, Japan

National Hospital Organization Beppu Medical Center /ID# 247894; 🇯🇵 Beppu-shi, Oita, Japan

Konan Medical Center /ID# 246079; 🇯🇵 Kobe-shi, Hyogo, Japan

University of Tsukuba Hospital /ID# 242023; 🇯🇵 Tsukuba-shi, Ibaraki, Japan

Kawasaki Municipal Hospital /ID# 241162; 🇯🇵 Kawasaki-shi, Kanagawa, Japan

St. Marianna University School of Medicine Yokohama City Seibu Hospital /ID# 266803; 🇯🇵 Yokohama, Kanagawa, Japan

Kochi Health Sciences Center /ID# 241182; 🇯🇵 高知市, Kochi, Japan

Imamura General Hospital /ID# 234006; 🇯🇵 Kagoshima-shi, Kagoshima, Japan

Toranomon Hospital Kajigaya /ID# 256186; 🇯🇵 Kawasaki-shi, Kanagawa, Japan

Tohoku University Hospital /ID# 243757; 🇯🇵 Sendai-shi, Miyagi, Japan

Kurashiki Central Hospital /ID# 244205; 🇯🇵 Kurashiki-shi, Okayama, Japan

Kitano Hospital /ID# 248785; 🇯🇵 Osaka-shi, Osaka, Japan

Japanese Red Cross Osaka Hospi /ID# 248784; 🇯🇵 Osaka-shi, Osaka, Japan

Yao Tokushukai General Hospital /ID# 247884; 🇯🇵 Yao City, Osaka, Japan

Ageo Central General Hospital /ID# 254515; 🇯🇵 Ageo-shi, Saitama, Japan

Shinkuki General Hospital /ID# 254516; 🇯🇵 Kuki-shi, Saitama, Japan

National Hospital Organization Hamada Medical Center /ID# 250858; 🇯🇵 Hamada City, Shimane, Japan

Masuda Red Cross Hospital /ID# 248780; 🇯🇵 Masuda-shi, Shimane, Japan

St.Luke's International Hospital /ID# 248787; 🇯🇵 Chuo-ku, Tokyo, Japan

Fussa Hospital /ID# 240570; 🇯🇵 Fussa, Tokyo, Japan

Juntendo Univ Nerima Hospital /ID# 250292; 🇯🇵 Nerima-ku, Tokyo, Japan

Almeida Memorial Hospital /ID# 241916; 🇯🇵 Oita City, Oita, Japan

Kawasaki Medical School Hospital /ID# 242709; 🇯🇵 Kurashiki-shi, Okayama, Japan

Duplicate_Okayama University Hospital /ID# 243755; 🇯🇵 Okayama-shi, Okayama, Japan

University of the Ryukyus Hospital /ID# 246821; 🇯🇵 Nakagami-gun, Okinawa, Japan

Osaka Women's and Children's Hospital /ID# 266805; 🇯🇵 Izumi-Shi, Osaka, Japan

Kishiwada City Hospital /ID# 234002; 🇯🇵 Kishiwada-shi, Osaka, Japan

Kaneda Hospital /ID# 238757; 🇯🇵 Maniwa, Okayama, Japan

Duplicate_Okayama University Hospital /ID# 240887; 🇯🇵 Okayama-shi, Okayama, Japan

Ishikiriseiki Hospital /ID# 246077; 🇯🇵 東大阪市, Osaka, Japan

TMG Asaka Medical Center /ID# 238761; 🇯🇵 Asaka-shi, Saitama, Japan

Saitama Citizens Medical Center /ID# 252573; 🇯🇵 Saitama-shi, Saitama, Japan

Tokushima Prefecture Naruto Hospital /ID# 239095; 🇯🇵 Naruto-shi, Tokushima, Japan

National Hospital Organization Osaka National Hospital /ID# 238764; 🇯🇵 Osaka-shi, Osaka, Japan

Daini Osaka Police Hospital /ID# 240560; 🇯🇵 Osaka-shi, Osaka, Japan

Otemae Hospital /ID# 250857; 🇯🇵 Osaka-shi, Osaka, Japan

Osaka Metropolitan University Hospital /ID# 253203; 🇯🇵 Osaka-shi, Osaka, Japan

Osaka Medical and Pharmaceutical University Hospital /ID# 249440; 🇯🇵 Takatsuki-shi, Osaka, Japan

NHO Saitama National Hospital /ID# 245061; 🇯🇵 Wako-shi, Saitama, Japan

Tokyo Metropolitan Children's Medical Center /ID# 252189; 🇯🇵 Fuchu City, Tokyo, Japan

Tama Medical Center /ID# 247954; 🇯🇵 Fuchu, Tokyo, Japan

Ogori Daiichi General Hospital /ID# 246761; 🇯🇵 Yamaguchi City, Yamaguchi, Japan

Harasanshin Hospital /ID# 240881; 🇯🇵 Fukuoka-shi, Japan

Hiroshima Prefecture Hospital /ID# 252215; 🇯🇵 Hiroshima, Japan

Nankai Medical Center /ID# 241914; 🇯🇵 Saiki-shi, Japan

Takatsuki Red Cross Hospital /ID# 266756; 🇯🇵 Takatsuki, Japan

Center hospital of the National Center for Global Health and Medicine /ID# 256189; 🇯🇵 Shinjuku-ku, Tokyo, Japan

Tokushima University Hospital /ID# 252572; 🇯🇵 Tokushima-shi, Tokushima, Japan

Tama-Hokubu Medical Center /ID# 245879; 🇯🇵 Higashimurayama-shi, Tokyo, Japan

Kainan Medical Center /ID# 240825; 🇯🇵 海南市, Wakayama, Japan

Yamaguchi University Hospital /ID# 245060; 🇯🇵 Ube-shi, Yamaguchi, Japan

Nihonkai General Hospital /ID# 242024; 🇯🇵 Sakata-shi, Japan

Duplicate_Teikyo University Hospital /ID# 247896; 🇯🇵 Itabashi-ku, Tokyo, Japan

NTT Medical Center Tokyo /ID# 240566; 🇯🇵 Shinagawa-ku, Tokyo, Japan

Medical Plaza Edogawa /ID# 244220; 🇯🇵 Edogawa Ward, Tokyo, Japan

Eiju General Hospital /ID# 243763; 🇯🇵 Taito, Tokyo, Japan

National Hospital Organization Chiba Medical Center /ID# 266755; 🇯🇵 Chiba, Japan

Tachikawa Hospital /ID# 245878; 🇯🇵 Tachikawa, Japan

National Center for Child Health and Development /ID# 243778; 🇯🇵 Setagaya-ku, Tokyo, Japan

Meirikai Chuo General Hospital /ID# 238751; 🇯🇵 Bei Qu, Tokyo, Japan

Tokyo Medical And Dental University Hospital /ID# 242178; 🇯🇵 Bunkyo-ku, Tokyo, Japan

Okitama Public General Hospital /ID# 242710; 🇯🇵 Higashiokitama-gun, Yamagata, Japan

Tokyo Metropolitan Geriatric /ID# 249448; 🇯🇵 Itabashi-ku, Tokyo, Japan

Japanese Red Cross Medical Center /ID# 239385; 🇯🇵 Shibuya-ku, Tokyo, Japan

Toshima Hospital /ID# 240878; 🇯🇵 板橋区, Tokyo, Japan

Tottori Prefectural Central Ho /ID# 245877; 🇯🇵 Tottori-shi, Tottori, Japan

Yonago Medical Center /ID# 240572; 🇯🇵 Yonago-shi, Tottori, Japan

NHO Iwakuni Clinical Center /ID# 242170; 🇯🇵 Iwakuni-shi, Yamaguchi, Japan

Inoue Memorial Hospital /ID# 239351; 🇯🇵 Chiba, Japan

Kitakyusyu General Hospital /ID# 244212; 🇯🇵 Kitakyushu-shi, Japan

Saitama City Hospital /ID# 240567; 🇯🇵 Saitama, Japan

Nagoya City West Medical Center /ID# 250844; 🇯🇵 Nagoya-shi, Aichi, Japan

National Center for Geriatrics and Gerontology /ID# 251683; 🇯🇵 Obu-shi, Aichi, Japan

Chiba University Hospital /ID# 246011; 🇯🇵 Chiba-shi, Chiba, Japan

National Cancer Center Hospital East /ID# 241917; 🇯🇵 Kashiwa-shi, Chiba, Japan

Japanese Red Cross Narita Hospital /ID# 243775; 🇯🇵 Narita-shi, Chiba, Japan

Fukuiken Saiseikai Hospital /ID# 246005; 🇯🇵 Fukui-shi, Fukui, Japan

Saiseikai Fukuoka Genaral Hospital /ID# 255193; 🇯🇵 Fukuoka-shi, Fukuoka, Japan

NHO Kokura Medical Center /ID# 257008; 🇯🇵 Kitakyusyu-shi, Fukuoka, Japan

St. Mary's Hospital /ID# 242332; 🇯🇵 Kurume-shi, Fukuoka, Japan

Kurume University Hospital /ID# 240885; 🇯🇵 Kurume-shi, Fukuoka, Japan

Omuta City Hospital /ID# 246823; 🇯🇵 Omuta-shi, Fukuoka, Japan

Kita Fukushima Medical Center /ID# 250296; 🇯🇵 Date-shi, Fukushima, Japan

Tokiwakai Jyoban Hospital /ID# 257007; 🇯🇵 Iwaki-shi, Fukushima, Japan

Ohta Nishinouchi Hospital /ID# 243052; 🇯🇵 Koriyama-shi, Fukushima, Japan

Iwaki Kyoritsu General Hospital /ID# 260209; 🇯🇵 Iwaki-shi, Fukushima, Japan

Shirakawa Kosei General Hosp. /ID# 245815; 🇯🇵 Shirakawa-shi, Fukushima, Japan

Gifu Municipal Hospital /ID# 241156; 🇯🇵 Gifu-shi, Gifu, Japan

Gifu University Hospital /ID# 241183; 🇯🇵 Gifu-shi, Gifu, Japan

Gifu Red Cross Hospital /ID# 240562; 🇯🇵 Gifu-shi, Gifu, Japan

Japanese Red Cross Takayama Hospital /ID# 240568; 🇯🇵 高山市, Gifu, Japan

Gunmaken Saiseikai Maebashi Hospital /ID# 239383; 🇯🇵 Maebashi-shi, Gunma, Japan

Fujioka General Hospital /ID# 255196; 🇯🇵 Fujioka-shi, Gunma, Japan

Gunma Prefectural Cancer Center /ID# 242177; 🇯🇵 Ota-shi, Gunma, Japan

Tatebayashi Kosei General Hospital /ID# 252188; 🇯🇵 Tatebayashi-shi, Gunma, Japan

National Hospital Organization Shibukawa Medical Center /ID# 245026; 🇯🇵 Shibukawa-shi, Gunma, Japan

Mihara Shiromachi Hospital /ID# 246754; 🇯🇵 Mihara, Hiroshima, Japan

NHO Hiroshima-Nishi Medical center /ID# 238766; 🇯🇵 Otake-shi, Hiroshima, Japan

Aiiku Hospital /ID# 239047; 🇯🇵 Sapporo-shi, Hokkaido, Japan

Sunagawa City Medical Center /ID# 239382; 🇯🇵 Sunagawa, Hokkaido, Japan

Wakkanai City Hospital /ID# 243782; 🇯🇵 Wakkanai City, Hokkaido, Japan

Ako Central Hospital /ID# 239721; 🇯🇵 Ako-shi, Hyogo, Japan

Kita-harima Medical Center /ID# 254490; 🇯🇵 Ono-shi, Hyogo, Japan

Shinko Hospital /ID# 233782; 🇯🇵 Kobe-shi, Hyogo, Japan

Hyogo Prefectural Awaji Medical Center /ID# 240823; 🇯🇵 洲本市, Hyogo, Japan

Hitachi General Hospital /ID# 239376; 🇯🇵 Hitachi-shi, Ibaraki, Japan

Iwate Prefectural Isawa Hospital /ID# 246819; 🇯🇵 Oshu-shi, Iwate, Japan

JCHO Kanazawa Hospital /ID# 239379; 🇯🇵 Kanazawa-Shi, Ishikawa, Japan

Sakaide City Hospital /ID# 240563; 🇯🇵 Sakaide City, Kagawa, Japan

Imakiire General Hospital /ID# 258237; 🇯🇵 Kagoshima-shi, Kagoshima, Japan

Shonan Kamakura General Hospital /ID# 243053; 🇯🇵 Kamakura-shi, Kanagawa, Japan

National Hospital Organization Kumamoto Medical Center /ID# 240886; 🇯🇵 Kumamoto-shi, Kumamoto, Japan

Kumamoto Kenhoku Hospital /ID# 258240; 🇯🇵 Tamana-shi, Kumamoto, Japan

Kumamoto Shinto General Hospital /ID# 242176; 🇯🇵 Kumamoto-shi, Kumamoto, Japan

Kumamoto Minami National Hospital /ID# 242169; 🇯🇵 Uki, Kumamoto, Japan

University Hospital Kyoto Prefectural University of Medicine /ID# 244843; 🇯🇵 Kyoto-shi, Kyoto, Japan

JCHO Kyoto Kuramaguchi Medical /ID# 248775; 🇯🇵 Kyoto-shi, Kyoto, Japan

JCHO Kumamoto General Hospital /ID# 248779; 🇯🇵 Yatsushiro City, Kumamoto, Japan

Japanese Red Cross Kyoto Daiichi Hosital /ID# 248124; 🇯🇵 Kyoto-shi, Kyoto, Japan

National Hospital Organization Kyoto Medical Center /ID# 239092; 🇯🇵 Kyoto-shi, Kyoto, Japan

Takeuchi Hospital /ID# 238750; 🇯🇵 津市, Mie, Japan

Uji Tokushukai Medical Center /ID# 241876; 🇯🇵 Uji-shi, Kyoto, Japan

Miyagi Cancer Center /ID# 241879; 🇯🇵 Natori-shi, Miyagi, Japan

Osaki Citizen Hospital /ID# 249447; 🇯🇵 Osaki-shi, Miyagi, Japan

Miyagi Chuo Hospital /ID# 259511; 🇯🇵 Sendai-shi, Miyagi, Japan

National Hospital Organization Sendai Medical Center /ID# 239384; 🇯🇵 Sendai-shi, Miyagi, Japan

Miyazaki Prefectural Nobeoka Hospital /ID# 248715; 🇯🇵 Nabeoka-shi, Miyazaki, Japan

University of Miyazaki Hospital /ID# 248805; 🇯🇵 Miyazaki-shi, Miyazaki, Japan

Jap Red Cross Nagasaki Genbaku /ID# 245029; 🇯🇵 Nagasaki-shi, Nagasaki, Japan

NHO Nagasaki Medical Center /ID# 240571; 🇯🇵 Omura-shi, Nagasaki, Japan

Nagasaki Goto Chuoh Hospital /ID# 239723; 🇯🇵 Goto-shi, Nagasaki, Japan

Sasebo City General Hospital /ID# 238759; 🇯🇵 Sasebo-shi, Nagasaki, Japan

Kyushu University Beppu Hospital /ID# 249444; 🇯🇵 Beppu-shi, Oita, Japan

Niigata University Medical & Dental Hospital /ID# 245027; 🇯🇵 Niigata-shi, Niigata, Japan

Oita Memorial Hospital /ID# 246818; 🇯🇵 Oita-shi, Oita, Japan

Oita University Hospital /ID# 261976; 🇯🇵 Yufu City, Oita, Japan

Okayama Medical Center /ID# 243759; 🇯🇵 Okayama-shi, Okayama, Japan

Japanese Red Cross Okayama Hospital /ID# 240879; 🇯🇵 Okayama-shi, Okayama, Japan

Nakagami Hospital /ID# 243787; 🇯🇵 Okinawa-shi, Okinawa, Japan

Kansai Medical University Hospital /ID# 246820; 🇯🇵 Hirakata-shi, Osaka, Japan

Shiroyama Hospital /ID# 246762; 🇯🇵 Habikino-shi, Osaka, Japan

Izumi City General Hospital /ID# 253204; 🇯🇵 Izumi-shi, Osaka, Japan

Osaka Saiseikai Nakatsu Hospital /ID# 244209; 🇯🇵 Osaka-shi, Osaka, Japan

Seijukai Hospital /ID# 248788; 🇯🇵 Neyagawa City, Osaka, Japan

Osaka International Cancer Institute /ID# 248783; 🇯🇵 Osaka-shi, Osaka, Japan

Osaka City General Hospital /ID# 244210; 🇯🇵 Osaka-shi, Osaka, Japan

Nippon Life Saiseikai Public Interest Foundation Nippon Life Hospital /ID# 243783; 🇯🇵 Osaka-shi, Osaka, Japan

Hara Hospital /ID# 244846; 🇯🇵 泉大津市, Osaka, Japan

Saga Medical Center Koseikan /ID# 245816; 🇯🇵 Saga-shi, Saga, Japan

Kamifukuoka General Hospital /ID# 247890; 🇯🇵 Fujimino City, Saitama, Japan

Omi Medical Center /ID# 258233; 🇯🇵 Kusatsu-shi, Shiga, Japan

Saiseikai Shiga Hospital /ID# 239381; 🇯🇵 Ritto, Shiga, Japan

Shimane Prefectural Central Ho /ID# 247895; 🇯🇵 Izumo-shi, Shimane, Japan

Duplicate_Dokkyo Medical University Hospital /ID# 246764; 🇯🇵 Shimotsuga-gun, Tochigi, Japan

Shizuoka Saiseikai Genaral Hospital /ID# 239722; 🇯🇵 Shizuoka-shi, Shizuoka, Japan

Ishibashi General Hospital /ID# 243762; 🇯🇵 Shimotsuke City, Tochigi, Japan

Tochigi Cancer Center /ID# 249445; 🇯🇵 Utsunomiya-shi, Tochigi, Japan

Anan Medical Center /ID# 243781; 🇯🇵 Anan-shi, Tokushima, Japan

Juntendo University Hospital /ID# 239096; 🇯🇵 Bunkyo-ku, Tokyo, Japan

Toranomon Hospital /ID# 251010; 🇯🇵 Minato-ku, Tokyo, Japan

Kosei Chuo General Hospital /ID# 251011; 🇯🇵 Meguro-ku, Tokyo, Japan

Duplicate_The Cancer Institute Hospital Of JFCR /ID# 244216; 🇯🇵 Koto-ku, Tokyo, Japan

Mishuku Hospital /ID# 239378; 🇯🇵 Meguro-ku, Tokyo, Japan

Japanese Red Cross Musashino Hospital /ID# 246765; 🇯🇵 Musashino-shi, Tokyo, Japan

P_Ome Municipal General Hospital /ID# 248778; 🇯🇵 Ome, Tokyo, Japan

Metropolitan Research and Treatment Center for Blood Disorders /ID# 231384; 🇯🇵 Setagaya Ward, Tokyo, Japan

Tokyo Medical University Hospital /ID# 252571; 🇯🇵 Shinjuku-ku, Tokyo, Japan

Kawakita General Hospital /ID# 257009; 🇯🇵 Suginami-ku, Tokyo, Japan

Tokyo Metropolitan Bokutoh Hospital /ID# 241912; 🇯🇵 Sumida-ku, Tokyo, Japan

The Fraternity Memorial Hospital /ID# 251685; 🇯🇵 Sumida-ku, Tokyo, Japan

Tottori University Hospital /ID# 244215; 🇯🇵 Yonago-shi, Tottori, Japan

Kurobe City Hospital /ID# 254493; 🇯🇵 Kurobe-shi, Toyama, Japan

Social Insurance Kinan Hosp /ID# 251684; 🇯🇵 Tanabe-shi, Wakayama, Japan

Wakayama Rosai Hospital /ID# 250293; 🇯🇵 Wakayama-shi, Wakayama, Japan

Yamagata University Hospital /ID# 246763; 🇯🇵 Yamagata-shi, Yamagata, Japan

Naga municipal Hospital /ID# 250259; 🇯🇵 Kinokawa City, Wakayama, Japan

Tokuyama Central Hospital /ID# 242380; 🇯🇵 Shunan-shi, Yamaguchi, Japan

University of Yamanashi Hospital /ID# 246006; 🇯🇵 Chuo-shi, Yamanashi, Japan

Fujisawa City Hospital /ID# 239375; 🇯🇵 Fujisawa-shi, Japan

Hachinohe Red Cross Hospital /ID# 250850; 🇯🇵 Hachinohe-shi, Japan

Tokai University Hachioji Hospital /ID# 266804; 🇯🇵 Hachioji, Japan

Higashihiroshima Medical Center /ID# 250849; 🇯🇵 Higashihiroshima-shi, Japan

Kawaguchi Municipal Medical Center /ID# 246080; 🇯🇵 Kawaguchi-shi, Japan

Ikeda City Hospital /ID# 266802; 🇯🇵 Ikeda, Japan

Kyorin University - Mitaka Campus /ID# 243777; 🇯🇵 Mitaka, Japan

Toshiba General Hospital /ID# 250294; 🇯🇵 Tokyo, Japan

Shonai Hospital /ID# 254514; 🇯🇵 Yamagata, Japan

Toyama Hospital /ID# 243779; 🇯🇵 Toyama, Japan