Neurophysiological Characteristics of Subthalamic Deep-brain Stimulation (STN-DBS)

Withdrawn

• Conditions: Parkinson Disease; Dystonia
• Interventions: Other: No intervention used

• Registration Number: NCT04707638
• Lead Sponsor: Wuhan Union Hospital, China

Brief Summary

The intraoperative neuroelectrophysiological signals were collected from patients undergoing STN-DBS under general anesthesia in the Neurosurgery Department of Wuhan union Hospital, and their preoperative conditions and postoperative efficacy will be evaluated.

Detailed Description

The intraoperative neuroelectrophysiological signals were collected from patients undergoing STN-DBS under general anesthesia in the Neurosurgery Department of Wuhan union Hospital, and their preoperative conditions and postoperative efficacy will be evaluated. The intraoperative neuroelectrophysiological signals would be analyzed.

Study Timeline

• Status Verified: 2021-01
• Study Start: 2021-01-01
• Study First Submitted: 2021-01-11
• Study First Submitted QC: 2021-01-12
• Study First Posted: 2021-01-13
• Last Update Submitted: 2021-01-31
• Last Update Posted: 2021-02-03
• Primary Completion: 2023-01-11
• Study Completion: 2023-01-11

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Patients underwentSTN-DBS in neurosurgery department of Wuhan Union Hospital.
2. Patients with Parkinson's disease or dystonia.

Exclusion Criteria

1.Patients without enough follow-up length.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Parkinson's disease or dystonia patients	No intervention used	Patients with Parkinson's disease or dystonia and underwent STN DBS under general anesthesia in neurosurgery department

Primary Outcome Measures

Name	Time	Method
Unified Parkinson's Disease Rating Scale (UPDRS)	Two years postoperatively	UPDRS has four parts: part I (nonmotor experiences of daily living, total score=16); part II (patient motor experience of daily living, total score=52); part III (clinician motor examination, total score=56); part IV (complications, total score=23). The total score of all the four parts is147. Higher scores means a worse outcome.
Burke Fahn Marsden's Dystonia Rating Scales(BFMDRS)	Two years postoperatively	BFMDRS has two parts: BFMDRS movement part (BFMDRS-M) and BFMDRS disability part (BFMDRS-D). The total score of BFMDRS-M is 120 and the total score of BFMDRS-D is 30. Higher scores means a worse outcome.