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Hyporesponsiveness of Natural Killer Cells and a Dysfunctional Inflammatory Response in Critically Ill Patients

Completed
Conditions
Critical Illness
Registration Number
NCT02565589
Lead Sponsor
Yonsei University
Brief Summary

To investigate natural killer (NK) cell activities, circulating cytokine levels and peripheral blood mononuclear cell (PBMC) cytokine production status in critically ill patients.

Detailed Description

Blood samples were collected \< 24 hours after admission from 24 intensive care unit (ICU) patients and 24 age-, sex-, and body mass index (BMI)-matched healthy controls. NK cell activities, cytokine concentrations and cytokine production by PBMCs and lipopolysaccharide (LPS)-stimulated PBMCs were measured.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
48
Inclusion Criteria
  • ICU patients
  • For healthy controls: nondiabetic and nonobese subjects
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Exclusion Criteria
  • For healthy controls: diabetes; history/presence of significant metabolic disease; pregnancy or breast-feeding; acute or chronic infection; liver disease; kidney disease; gastrointestinal disease; subjects taking any drugs or supplements
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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
NK cell activityBaseline

NK cell activity (%)

Secondary Outcome Measures
NameTimeMethod
IL (Interleukin)-12Baseline

IL-12 (pg/mL)

hs-CRP (high-sensitivity C-reactive protein)Baseline

hs-CRP (mg/dL)

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