Hyporesponsiveness of Natural Killer Cells and a Dysfunctional Inflammatory Response in Critically Ill Patients
Completed
- Conditions
- Critical Illness
- Registration Number
- NCT02565589
- Lead Sponsor
- Yonsei University
- Brief Summary
To investigate natural killer (NK) cell activities, circulating cytokine levels and peripheral blood mononuclear cell (PBMC) cytokine production status in critically ill patients.
- Detailed Description
Blood samples were collected \< 24 hours after admission from 24 intensive care unit (ICU) patients and 24 age-, sex-, and body mass index (BMI)-matched healthy controls. NK cell activities, cytokine concentrations and cytokine production by PBMCs and lipopolysaccharide (LPS)-stimulated PBMCs were measured.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
- ICU patients
- For healthy controls: nondiabetic and nonobese subjects
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Exclusion Criteria
- For healthy controls: diabetes; history/presence of significant metabolic disease; pregnancy or breast-feeding; acute or chronic infection; liver disease; kidney disease; gastrointestinal disease; subjects taking any drugs or supplements
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method NK cell activity Baseline NK cell activity (%)
- Secondary Outcome Measures
Name Time Method IL (Interleukin)-12 Baseline IL-12 (pg/mL)
hs-CRP (high-sensitivity C-reactive protein) Baseline hs-CRP (mg/dL)