4 Cities for Assessing CAlcification PRognostic Impact After TAVI
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Disease
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 1600
- Locations
- 1
- Primary Endpoint
- Cardiovascular mortality
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Transcatheter Aortic Valve Implantation (TAVI) indications are progressing rapidly as an alternative to conventional surgery for aortic stenosis cure. Despite a high rate of procedural success, some patients do not benefit from the procedure. The investigators hypothesis is that aortic stiffness may be of major prognostic significance after stenosis relief.
The aim of this study is to test the prognostic impact of aortic stiffness estimated by the volume of calcifications of the thoracic aorta on the CT-scan performed systematically before the procedure. This prognostic value will be assessed in 4 independent cohorts issued from 4 french cities (Lyon, Rouen, Paris, Clermont-Ferrand).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age \> 18
- •Patient who underwent a transcatheter aortic valve implantation
- •Patient who provided informed, written consent to participate to FRANCE TAVI study
- •Patient for whom a CT-Scan performed before TAVI procedure is available.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Cardiovascular mortality
Time Frame: censored on 3 March 2017
Number of death of cardiovascular cause will be analyzed
Secondary Outcomes
- All-cause deaths(censored on 3 March 2017)
- left ventricular remodeling(censored on 3 March 2017)
- left ventricular ejection fraction(censored on 3 March 2017)
- diastolic function(censored on 3 March 2017)