4 Cities for Assessing CAlcification PRognostic Impact After TAVI
- Conditions
- Heart Disease
- Registration Number
- NCT02935491
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
Transcatheter Aortic Valve Implantation (TAVI) indications are progressing rapidly as an alternative to conventional surgery for aortic stenosis cure. Despite a high rate of procedural success, some patients do not benefit from the procedure. The investigators hypothesis is that aortic stiffness may be of major prognostic significance after stenosis relief.
The aim of this study is to test the prognostic impact of aortic stiffness estimated by the volume of calcifications of the thoracic aorta on the CT-scan performed systematically before the procedure. This prognostic value will be assessed in 4 independent cohorts issued from 4 french cities (Lyon, Rouen, Paris, Clermont-Ferrand).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1600
- Age > 18
- Patient who underwent a transcatheter aortic valve implantation
- Patient who provided informed, written consent to participate to FRANCE TAVI study
- Patient for whom a CT-Scan performed before TAVI procedure is available.
- none
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cardiovascular mortality censored on 3 March 2017 Number of death of cardiovascular cause will be analyzed
- Secondary Outcome Measures
Name Time Method All-cause deaths censored on 3 March 2017 Number of death of all causes will be analyzed
left ventricular remodeling censored on 3 March 2017 Echocardiographic measure will be done
left ventricular ejection fraction censored on 3 March 2017 Echocardiographic measure will be done
diastolic function censored on 3 March 2017 Echocardiographic measure will be done
Trial Locations
- Locations (1)
Hôpital de la Croix Rousse
🇫🇷Lyon, France
Hôpital de la Croix Rousse🇫🇷Lyon, France