Non-hormonal Medical Device for Treatment of Vulvovaginal Atrophy (VVA) in Post-Menopausal Women
- Conditions
- Vulvovaginal Atrophy
- Interventions
- Device: Non-hormonal vaginal device therapyDevice: Sham vaginal device therapy
- Registration Number
- NCT04887701
- Lead Sponsor
- Madorra
- Brief Summary
Randomized (1:1), double-blind, sham-controlled, 2-arm parallel study comparing effectiveness and safety of non-hormonal medical device versus sham device to treat VVA in post-menopausal women.
- Detailed Description
After screening and baseline assessment, participants, ages 21 to 65 years of age, will be randomized and followed for a 12-week intervention period. After the primary endpoint evaluation at week 12, each participant in both arms will immediately commence an open label period using an Active device for week 13 to 1 year to collect further effectiveness and safety data.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 25
- Women with menopause defined by last menstrual period at least 12 months prior to screening, or 6 months of amenorrhea with serum FSH levels > 40 mIU/ml, or 8 weeks postsurgical bilateral oophorectomy with or without hysterectomy.
- Sexually active women.
- Participant experiencing subjective moderate-to-severe vaginal pain with sexual intercourse.
- Participant experiencing subjective moderate-to-severe vaginal dryness.
- Gynecological exam confirming vaginal atrophy.
- Willingness to give voluntary written informed consent to participate in the study and comply with protocol requirements.
- Use of systemic or local estrogen therapy, currently or in the last 6 months or planned use during the study.
- Use of any other treatment for vaginal atrophy, 6 weeks prior to enrollment or planned during the study period.
- Investigational drugs and also prescription and nonprescription medications/remedies known to treat VVA within 60 days of enrollment or during the study.
- Vaginal stenosis.
- Pelvic floor disorders.
- Prior pelvic radiation therapy including radiation or surgery to the vulva/vagina.
- Active urinary tract, yeast, or other active gynecologic infections.
- Active connective tissue disorders such as lupus or Sjogren's syndrome.
- Active malignancies.
- Diagnosis of vulvodynia or other pelvic pain in the vagina or vulvar area.
- Vulvar dermatoses.
- Laser or radio frequency vaginal rejuvenation treatment or planned treatment during the study.
- Any medical condition that, in the investigator's opinion, would interfere with their participation and/or completion in the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Non-hormonal device therapy Non-hormonal vaginal device therapy Daily non-hormonal device therapy Sham Therapy Sham vaginal device therapy Daily non-hormonal sham device therapy
- Primary Outcome Measures
Name Time Method Patient Reported VAS Score Baseline to 12 weeks Mean change in the Vaginal Assessment Scale (VAS). The VAS is a scale from 0 to 3 with 0 being no symptoms and 3 being severe symptoms.
Clinician Assessed Changes in VVA Baseline to 12 weeks Will determine by comparing the mean change between the two arms of the study in clinician assessed changes of VVA by the Vaginal Health Index (VHI). The VHI gives a numerical score (1-5) for each of the 5 parameters measured:
issue elasticity, vaginal fluid, PH, mucosa, and vaginal moisture.
- Secondary Outcome Measures
Name Time Method Responder Rate PGI-I 12 weeks The proportion of patients in the two arms of the study achieving improvement in the patient global impression of improvement (PGI-I), (much or very much improved) at 12 weeks post-treatment.
Trial Locations
- Locations (3)
North Shore Private Hospital
🇦🇺Sydney, New South Wales, Australia
Goldfields Urology
🇦🇺Bendigo, Victoria, Australia
Royal Women's Hospital
🇦🇺Melbourne, Victoria, Australia