Response to Endotracheal Tube Intubation at Different Time of Fentanyl Given During Induction
- Conditions
- Intubation, Intratracheal
- Interventions
- Other: Different given time
- Registration Number
- NCT03728686
- Lead Sponsor
- Chien-Chung,Huang
- Brief Summary
Opioids have been used to modify the hemodynamic response associated with laryngoscopy and tracheal intubation. To seek the correlation of Fentanyl given time, we will analysis the data collected from vital signs monitoring machine. Patients'details will be recorded too.
- Detailed Description
Laryngoscopy and intubation often provoke hypertension and tachycardia due to the stimulation both sympathetic and sympathoadrenal activities. While the adverse hemodynamic effects of laryngoscopy and endotracheal intubation can precipitate myocardial ischemia, even in patients without hypertension, the responses are exaggerated in patients with hypertension . In the previous studies , many drugs, including opioids and beta-blockers, have been used to modify the hemodynamic response associated with laryngoscopy and tracheal intubation. To seek the correlation of Fentanyl given time, we will analysis the data collected from vital signs monitoring machine.
All patients were premedicated with Midazolam 0.1mg/kg , Lidocaine 0.5mg/kg (L), Propofol 2mg/kg (P), Rocuronium 1mg/kg (R) before induction of general anesthesia. Laryngoscopy lasting a maximum of 30 s was attempted 3 min after administration of the induction agents. Fentanyl 2mcg/kg was given at different time before intubation.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 101
- with American Society of Anesthesiologists (ASA) physical status classification 1&2
- undergo elective surgery
- intubation
- Opioids allergy history
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 3mins Different given time Different given time: Fentanyl 2mcg/kg was given at either time 3 minutes before intubation 2mins Different given time Different given time: Fentanyl 2mcg/kg was given at either time 2 minutes before intubation
- Primary Outcome Measures
Name Time Method systolic blood pressure 0-10 minutes during induction systolic blood pressure
heart rate 0-10 minutes during induction heart rate
diastolic blood pressure 0-10 minutes during induction diastolic blood pressure
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
MacKay Memorial Hospital
🇨🇳Taipei, Taiwan