Is There a Toll-like 4 Receptor Relationship in Patients With Testicular Torsion?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 主要终点
- Toll-like receptor 4 positives or negative
研究概览
简要总结
Background:
Testicular torsion is a scrotal emergency that results in impaired blood supply to the testis and ischemia of the testis as a result of the rotation of the spermatic cord around itself. The etiology of testicular torsion is not clear, but various predisposing factors are responsible for the occurrence of testicular torsion.
Recently, with the discovery of "Toll-Like Receptors" (TLRs), new horizons have been opened in the field of innate immune system-related diseases.
Objective: To mediate the relationship between testicular torsion and TLR4 receptors.
Material-Method: Testicular specimens of patients who developed testicular ischemia after testicular torsion and underwent orchiectomy between 2012-2022 were reached. A study of TLR 4 receptors was performed in these testicular specimens. The patients were divided into two groups according to their ages newborns and adolescents.
详细描述
Analysis of 32 newborns and 32 adolescents between the ages of 14 and 16 (mean age was 15.17 ± 0.98) testicular tissue lysate using Toll-Like Receptor antibody 4 (TLR4) ELISA (Enzyme-Linked ImmunoSorbent Assay).
Toll-like receptor 4 is a transmembrane protein that in humans is encoded by the TLR4 gene. Its activation leads to the production of inflammatory cytokines.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 0 Days 至 16 Years（Child）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •testicular torsion
- •newborn, adolescent,
排除标准
- •orchitis, urinary infection, trauma,
结局指标
主要结局
Toll-like receptor 4 positives or negative
时间窗: 10 years
testicular torsion
次要结局
未报告次要终点
研究者
Basri Cakiroglu
Ass. Prof.
Hisar Intercontinental Hospital