Testicular Torsion

Not Applicable

Completed

• Conditions: Testicular Torsion and TLR 4 Was Investigated
• Interventions: Genetic: Toll-like receptor 4

• Registration Number: NCT05558072
• Lead Sponsor: Hisar Intercontinental Hospital

Brief Summary

Background:

Testicular torsion is a scrotal emergency that results in impaired blood supply to the testis and ischemia of the testis as a result of the rotation of the spermatic cord around itself. The etiology of testicular torsion is not clear, but various predisposing factors are responsible for the occurrence of testicular torsion.

Recently, with the discovery of "Toll-Like Receptors" (TLRs), new horizons have been opened in the field of innate immune system-related diseases.

Objective: To mediate the relationship between testicular torsion and TLR4 receptors.

Material-Method: Testicular specimens of patients who developed testicular ischemia after testicular torsion and underwent orchiectomy between 2012-2022 were reached. A study of TLR 4 receptors was performed in these testicular specimens. The patients were divided into two groups according to their ages newborns and adolescents.

Detailed Description

Analysis of 32 newborns and 32 adolescents between the ages of 14 and 16 (mean age was 15.17 ± 0.98) testicular tissue lysate using Toll-Like Receptor antibody 4 (TLR4) ELISA (Enzyme-Linked ImmunoSorbent Assay).

Toll-like receptor 4 is a transmembrane protein that in humans is encoded by the TLR4 gene. Its activation leads to the production of inflammatory cytokines.

Study Timeline

• Study Start: 2012-01-01
• Primary Completion: 2021-12-30
• Study Completion: 2022-04-30
• Status Verified: 2022-09
• Study First Submitted: 2022-09-23
• Study First Submitted QC: 2022-09-23
• Last Update Submitted: 2022-09-23
• Study First Posted: 2022-09-28
• Last Update Posted: 2022-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 64

Inclusion Criteria

testicular torsion

• newborn, adolescent,

Exclusion Criteria

• orchitis, urinary infection, trauma,

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group 1	Toll-like receptor 4	Newborn
Group 2	Toll-like receptor 4	adolescent

Primary Outcome Measures

Name	Time	Method
Toll-like receptor 4 positives or negative	10 years	testicular torsion