Prevalence of Primary Aldosteronism in Patients With Stroke
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Percentage of patients with stroke with confirmed primary aldosteronism in patients admitted to the acute stroke unit for stroke
研究概览
简要总结
Strokes leads to significant morbidity and mortality, and hypertension is the most important risk factor for strokes. It is estimated that up to 10% of patients with hypertension have the underlying, treatable condition of primary aldosteronism. Hence, we hypothesize that the prevalence of primary aldosteronism is high in patients with strokes, a complication of long-standing hypertension.
Patients admitted with an acute stroke to the Acute Stroke Unit, Changi General Hospital, will be screened for Primary Aldosteronism three months post-stroke, and confirmatory tests will be done with saline-infusion test.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 21-80 years
- •Admitted with acute cerebrovascular accident (CVA) or transient ischemic attack (TIA) to the ASU, CGH
- •Patients with both ischemic and hemorrhagic strokes
排除标准
- •a. Pregnant patients
结局指标
主要结局
Percentage of patients with stroke with confirmed primary aldosteronism in patients admitted to the acute stroke unit for stroke
时间窗: 6 months
Percentage of patients with confirmed Primary Aldosteronism using confirmatory test
次要结局
- Percentage of patients with positive screening test in patients admitted with acute stroke(3 months)
- Blood pressure change after treatment for primary aldosteronism(12 months)
- Percentage of unilateral primary aldosteronism in patients admitted with acute stroke(6 months)
- Accuracy of Screening test in early period post-stroke(3 months)
- Cardiac Complications(6 months)