Prevalence of Primary Aldosteronism in Patients With Stroke
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Changi General Hospital
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Percentage of patients with stroke with confirmed primary aldosteronism in patients admitted to the acute stroke unit for stroke
Study Overview
Brief Summary
Strokes leads to significant morbidity and mortality, and hypertension is the most important risk factor for strokes. It is estimated that up to 10% of patients with hypertension have the underlying, treatable condition of primary aldosteronism. Hence, we hypothesize that the prevalence of primary aldosteronism is high in patients with strokes, a complication of long-standing hypertension.
Patients admitted with an acute stroke to the Acute Stroke Unit, Changi General Hospital, will be screened for Primary Aldosteronism three months post-stroke, and confirmatory tests will be done with saline-infusion test.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 21 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age 21-80 years
- •Admitted with acute cerebrovascular accident (CVA) or transient ischemic attack (TIA) to the ASU, CGH
- •Patients with both ischemic and hemorrhagic strokes
Exclusion Criteria
- •a. Pregnant patients
Outcomes
Primary Outcomes
Percentage of patients with stroke with confirmed primary aldosteronism in patients admitted to the acute stroke unit for stroke
Time Frame: 6 months
Percentage of patients with confirmed Primary Aldosteronism using confirmatory test
Secondary Outcomes
- Percentage of patients with positive screening test in patients admitted with acute stroke(3 months)
- Blood pressure change after treatment for primary aldosteronism(12 months)
- Percentage of unilateral primary aldosteronism in patients admitted with acute stroke(6 months)
- Accuracy of Screening test in early period post-stroke(3 months)
- Cardiac Complications(6 months)