Telephone-linked Home-based Exercise Training in PD
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Change in Hamilton Rating Scale for Depression (HAM-D) From Baseline to 6 Months
研究概览
简要总结
This project is investigating whether a home-based exercise program will reduce depression in patients with Parkinson's disease.
详细描述
Background/Rationale:
Nonmotor symptoms in Parkinson's disease (PD) are thought to be present from the early stages of disease and are often more disabling and resistant to treatment than motor symptoms. One of the most important and serious of these symptoms is depression. However, there is no consensus on best pharmacological treatment for depression in PD as efficacy is lacking and there is much concern about polypharmacy and safety of various antidepressant medications. Therefore, it is essential that the investigators characterize the effects of nonpharmacological interventions on depression in PD. A number of studies have shown significant benefits of exercise in reducing depressive symptoms. Emerging studies indicate similar benefits of exercise in the form of resistance training in limiting depression in older adults as well as in those with PD.
Objective:
The investigators hypothesize that a home-based exercise intervention will reduce depression in Veterans with depression in PD.
Methods:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Physician diagnosis of idiopathic, typical Parkinson's disease (PD)
- •At least 2 of 3 cardial signs of PD
- •Response to dopaminergic medication
- •Depression
排除标准
- •Angina pectoris
- •History of myocardial infarction within 6 months
- •History of ventricular dysrhythmia requiring current therapy
结局指标
主要结局
Change in Hamilton Rating Scale for Depression (HAM-D) From Baseline to 6 Months
时间窗: Baseline and 6 months
The HAM-D is the most widely used and accepted measure for evaluating depression severity. The HAM-D scores range from a minimum of 0 to a maximum of 50. Higher scores indicate more severe depression. Change = (6 month score) - (baseline score).
次要结局
未报告次要终点