Cardiovascular Medication Use Before First Myocardial Infarction

Completed

• Conditions: Myocardial Infarction

• Registration Number: NCT01692795
• Lead Sponsor: London School of Hygiene and Tropical Medicine

Brief Summary

Large randomised trials have shown that cardiovascular medications prescribed to patients at high cardiovascular risk are effective in reducing the incidence of cardiovascular events. Their use is recommended in the United Kingdom and international guidelines (e.g. the National Institute of Clinical Excellence). However, these medications do not prevent cardiovascular events in all patients and there is now a body of research investigating the effects of cardiovascular medications on outcomes in myocardial infarction (MI), including clinical presentation, infarct size and post-MI mortality. However, the independent effects of cardiovascular drugs on post-MI all cause mortality are unclear, and there are limitations to many of the published studies in terms of their cardiovascular drug exposure data. This project utilizes prospectively collected data on cardiovascular drug use, and links to MI data from hospital and mortality records.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-09
• Study First Submitted: 2012-09-21
• Study First Submitted QC: 2012-09-21
• Study First Posted: 2012-09-25
• Primary Completion: 2013-09
• Study Completion: 2013-09
• Status Verified: 2015-10
• Last Update Submitted: 2015-10-01
• Last Update Posted: 2015-10-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 17000

Inclusion Criteria

Patients in GPRD practices which are deemed "up to standard" by GPRD criteria will be included if their practice agreed to be linked to the Myocardial Ischaemic National Audit Project (MINAP), Hospital Episode Statistics (HES) and Office for National Statistics (ONS) datasets.

Patients must have at least one year of GPRD "up to standard" registration before the date of first myocardial infarction.

Age over 18. First myocardial infarction occurring between 1st January 2003 and 31st December 2008, as recorded in the HES data or MINAP.

Exclusion Criteria

Patients will be excluded if they do not fulfil one of the inclusion criteria.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All cause mortality	Up to seven years	All cause mortality, using Office for National Statistics (ONS) mortality statistics
Re-infarction	One year after initial myocardial infarction	Reinfarction will be measured based on data from the General Practice Research Database (GPRD), Hospital Episode Statistics (HES), the Myocardial Ischaemia National Audit Project (MINAP) and Office for National Statistics (ONS) mortality data.

Secondary Outcome Measures

Name	Time	Method
Myocardial infarciton (MI) type	Measured at baseline	Diagnosed ST-elevation MI or non ST-elevation myocardial infarction

Trial Locations

Locations (1)

London School of Hygiene and Tropical Medicine; 🇬🇧 London, United Kingdom