Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring
Phase 4
Terminated
- Conditions
- Traumatic Brain InjuryIntracranial Hypertension
- Interventions
- Drug: variation of mannitol dose
- Registration Number
- NCT00795587
- Lead Sponsor
- University Hospital, Grenoble
- Brief Summary
Will an increase of the dose of mannitol improve the effects on neuromonitoring in patients suffering intracranial hypertension following traumatic brain injury?
- Detailed Description
traumatic brain injury intracranial hypertension 0,4 g/ kg vs 0,8 g/ kg (randomized) on 20 minutes monitoring: ICP, transcranial doppler, brain pO2, MAP, HR, diuresis, biology duration: 2 hours
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 3
Inclusion Criteria
- adults
- severe traumatic brain injury
- intracranial hypertension requiring mannitol administration
Exclusion Criteria
- impeding neurosurgery
- hemodynamic or respiratory severe failure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description mannitol low dose variation of mannitol dose mannitol 20% 0,4 g/ kg on minutes mannitol high dose variation of mannitol dose mannitol 20% 0,8 g/ kg on minutes
- Primary Outcome Measures
Name Time Method intracranial pressure 2 hours
- Secondary Outcome Measures
Name Time Method brain PO2 2h transcranial doppler 2 h MAP 2h biology (blood gases, natremia, hematocrit) 2h fluid requirement 2h diuresis 2h Heart Rate 2h
Trial Locations
- Locations (1)
Universitary Hospital
🇫🇷Grenoble, France
Universitary Hospital🇫🇷Grenoble, France