Gastroesophageal reflux disease in children and adolescents: Diagnostic utility of the Post-reflux Swallow-induced Peristaltic Wave Index and Mean Nocturnal Baseline Impedance
Recruiting
- Conditions
- K21Gastro-oesophageal reflux disease
- Registration Number
- DRKS00032706
- Lead Sponsor
- niversitätskinderklinik Bochum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
Patients who received an EGD and a pH MII under sedation at the same time between 2015 and 2022 and who had aerosive gastroesophageal reflux disease or a non-erosive gastroesophageal reflux disease diagnosed or a macroscopically normal EGD and a normal pH MII
Exclusion Criteria
Proton pump inhibitor, antacid or steroid therapy in the four weeks before the endoscopic diagnosis
Presence of esophageal strictures
Presence of esophageal motility disorder (e.g. achalasia)
Presence of eosinophilic esophagitis
Presence of thrush esophagitis
Patients with corrected esophageal atresia
Patients with psychomotor disabilities
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in the PSPW index between children and adolescents with erosive gastroesophageal reflux disease, with non-erosive gastroesophageal reflux disease and a control group
- Secondary Outcome Measures
Name Time Method Differences of MNBI and simplified MNBI between children and adolescents with erosive gastroesophageal reflux disease, with non-erosive gastroesophageal reflux disease and a control group<br><br>Correlation of the novel ph MII parameters with the established standardized evaluated parameters<br><br>Differences of the novel pH MII parameters in children =12 months and children and adolescents >12 months and =18 years