NL-OMON32774
Completed
Not Applicable
Insight in affective versus non-affective psychosis: an fMRI study - Insight in psychosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- psychosis
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 100
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •A total of 40 Patients must have a diagnosis within the schizophrenia spectrum, either schizophrenia or schizophreniform disorder. A total of 40 patients must have a diagnosis within the mood disorders, either bipolar disorder or psychotic depression. All patients must have a history of psychosis as we are interested in insight in psychosis. All subjects must be cooperative, capable of lying still in a scanner for one hour and capable of performing the experimental tasks.
Exclusion Criteria
- •Patients may not use classical antipscychotic medication as it has been shown that this type of medication can influence the activation in the frontal cortices. Furthermore, patients may use a maximum of three Lorazepam equivalents, since they must be alert enough to perform the experimental tasks. Patients must be stable on their current medication and may not have had a change in medication in the week before scanning. In addition, patients may not have the diagnosis schizoaffective disorder as this diagnosis has been controversial, difficult to diagnose and patients who have had this diagnosis are often diagnosed with schizophrenia later in life. All subjects may not have a 'relevant' neurological disorder affecting the Central Nervous System for which they are treated nor may the psychiatric diagnosis have a somatic origin.
Outcomes
Primary Outcomes
Not specified
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