Metabolic Effects of Treatment of Chronic Periodontitis in Non-diabetic Subjects

Not Applicable

Completed

• Conditions: Prediabetes; Periodontitis
• Interventions: Procedure: non-surgical periodontal treatment

• Registration Number: NCT02830113
• Lead Sponsor: Yaounde Central Hospital

Brief Summary

This study was aimed at assessing the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C-reactive protein(CRP) level amongst non-diabetic subjects.

Detailed Description

Subjects with chronic periodontitis will undergo non-surgical periodontal treatment (NSPT) consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution. Periodontal parameters (plaque index, gingival bleeding index, pocket depth, and clinical attachment loss), insulin sensitivity using KITT, glucose tolerance using oral glucose tolerance test and serum CRP level by immunoturbidimetry will be measured before and 3 months after the NSPT.

Study Timeline

• Study Start: 2014-12
• Primary Completion: 2015-05
• Study Completion: 2015-09
• Status Verified: 2016-07
• Study First Submitted: 2016-07-08
• Study First Submitted QC: 2016-07-08
• Last Update Submitted: 2016-07-08
• Study First Posted: 2016-07-12
• Last Update Posted: 2016-07-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Chronic periodontitis
• Non diabetic individual

Exclusion Criteria

• Known diabetes
• Periodontal treatment less than 6 months prior to inclusion
• Having less than 20 natural teeth

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
non-surgical periodontal treatment	non-surgical periodontal treatment	One session of non-surgical periodontal treatment consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution.

Primary Outcome Measures

Name	Time	Method
Glucose tolerance	3 months	change in 2-hour post load blood glucose
Insulin sensitivity	3 months	change in glucose disappearance rate during the short insulin tolerance test

Secondary Outcome Measures

Name	Time	Method
Inflammation	3 months	change in Serum CRP
Composite periodontal health	3 months	Change in plaque index, gingival bleeding index, pocket depth, and clinical attachment loss