Effects of Non-surgical Treatment of Chronic Periodontitis on Insulin Resistance and Glucose Tolerance in Non-diabetic Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 主要终点
- Glucose tolerance
研究概览
简要总结
This study was aimed at assessing the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C-reactive protein(CRP) level amongst non-diabetic subjects.
详细描述
Subjects with chronic periodontitis will undergo non-surgical periodontal treatment (NSPT) consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution. Periodontal parameters (plaque index, gingival bleeding index, pocket depth, and clinical attachment loss), insulin sensitivity using KITT, glucose tolerance using oral glucose tolerance test and serum CRP level by immunoturbidimetry will be measured before and 3 months after the NSPT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Chronic periodontitis
- •Non diabetic individual
排除标准
- •Known diabetes
- •Periodontal treatment less than 6 months prior to inclusion
- •Having less than 20 natural teeth
研究组 & 干预措施
non-surgical periodontal treatment
One session of non-surgical periodontal treatment consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution.
干预措施: non-surgical periodontal treatment (Procedure)
结局指标
主要结局
Glucose tolerance
时间窗: 3 months
change in 2-hour post load blood glucose
Insulin sensitivity
时间窗: 3 months
change in glucose disappearance rate during the short insulin tolerance test
次要结局
- Inflammation(3 months)
- Composite periodontal health(3 months)
研究者
Sobngwi Eugene
Professor of Endocrinology and Diabetes
Yaounde Central Hospital