Effect of fluticasone propionate for the prevention of perioperative respiratory complications in children undergoing adenotonsillectomy who present with recurrent respiratory symptoms

Telethon Kids Institute0 个研究点目标入组 18 人开始时间: 2019年2月19日最近更新: 2021年7月5日

适应症

试验速览

暂无简介。

•4 > Age < 10
•Male/Female
•Adenotonsilectomy +/- adenoidectomy, grommets, cautery of inferior turbinates, or examination of the ear under general anaesthesia with the use of laryngeal mask airway or endotracheal tubes
•Respiratory symptoms in the past 12 months including:
•- shortness of breath
•- 4 weeks cough
•- exercise induced respiratory symptoms
•eNO measurement greater than or equal to 20 ppb

•4 > Age > 10
•Cystic Fibrosis, bronchiectasis
•Significant cardiac disease
•Preventer asthma medications other than the study intervention in the last 3 months such as:
•- Inhaled corticosteroids (other than the supplied study intervention e.g. budenoside, beclomethasone dipropionate, mometasone furoate, ciclesonide)
•- Long-acting beta agonists (other than study intervention) or an extended release short-acting beta-agonist
•- Leukotriene-receptor agonists (e.g. montelukast), theophylline, cromolyn, or other non-inhaled/oral corticosteroid asthma controller medications
•Prescription or over the counter medications that would significantly interact with beta-agonists or inhaled corticosteroids
•Potent Cytochrome P450 3A4 (CYP3A4) inhibitors within 4 weeks of Visit 1 and during the double-blind treatment period (e.g. clarithromycin, ritonavir, ketoconazole, itraconazole)
•Inhaled anti-cholinergics (e.g. tiotropium, ipratropium)
•Anti-IgE (e.g. Xolair [omalizumab])
•Other immunomodulators (e.g. azathioprine, cyclosporine, methotrexate)
•Anticonvulsants (barbiturates, hydantoins and carbamazepine)
•Polycyclic antidepressants
•beta-adrenergic blocking agents
•Phenothiazines
•Monoamine oxidase (MAO inhibitors)

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