Therapeutic strategies in acute middle cerebral artery occlusion: ultrasound enhanced intravenous t-PA versus additional endovascular treatment: a comparison of two centers

• Conditions: I63; Cerebral infarction

• Registration Number: DRKS00005305
• Lead Sponsor: eurologische KlinikUniversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-09-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Patients treated in the period between 01.07.2007 and 30.6.2013 in the respective hospitals who are >=18 yrs and received intravenous thrombolysis because of MCA occlusion and
2. in center A additionally intraarterial intervention, in center B additionally sonothrombolysis.

Exclusion Criteria

Patients with missing information about duration and type of sonothrombolysis

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of patients in both centers regarding early NIH improvement (delta NIH-SS and absolute NIH-SS at 24 h) and degree of disability (modified Rankin Scale, Barthel Index) at hospital discharge and at discharge from the rehabilitation clinic.

Secondary Outcome Measures

Name	Time	Method
Comparison of both therapeutic strategies regarding:<br>- Effect of clinical factors (age, sex, vascular risk factors, blood glucose etc.) on clinical outcome<br>- rate of symptomatic intracerebral hemorrhage<br>- other adverse events (angioedema, complications during angiography) for both therapeutic strategies<br>- size of infarction<br>- number of patients with early recanalization<br>