Cerebral Micro Emboli Signal Detection in Endocarditis. A prospective follow-up study

Recruiting

• Conditions: endocarditis; micro embolie detectie; ontsteking van het weefsel van de hartkamer; 10014662; 10014523

• Registration Number: NL-OMON54754
• Lead Sponsor: HagaZiekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 24 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

1. Proven left-tailed infective native endocarditis or bioprosthetic valves
endocarditis
2. ultrasound test of the heart not older than 2 weeks
3. 18 years and older
4. mentally competent
5. written informed consent

Exclusion Criteria

1. right-tailed endocarditis
2. left-tailed endocarditis with already an emergency indication for
heartsurgery/valve replacement (<24h)
3. lack of a temporal window
4. severe claustrophobia or other MRI contraindications
5. Clinical manifistations of an old/recent CVA
6. mechanical valve

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint: development of a CVA during the hospitalization</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary neurological endpoints are:<br /><br>1. The severity of the CVA at origin and after 3 months (NIHSS score), the type<br /><br>of CVA (ischemic or hemorrhage)<br /><br>2. Occurrence of TIA's,<br /><br>3. Occurrence of meningitis,<br /><br>4. developing a cerebral abscess/cerebritis,<br /><br>5. mortality,<br /><br>6. functional outcome after 3 months<br /><br>7. SWI/DWI/Flair and T2 lesions on MRI brain (after 3 months or <24h prior to<br /><br>surgery) in compare with inclusion MRI.<br /><br>8. Occurrence of a heart surgery or valve surgery after inclusion.</p><br>