Posterior Nasal Nerve Neurectomy for Treatment of Intractable Allergic Rhinitis

Not Applicable

Not yet recruiting

• Conditions: Intractable Allergic Rhinitis

• Registration Number: NCT06887842
• Lead Sponsor: Kafrelsheikh University

Brief Summary

This study aims to compare the outcomes of posterior nasal nerve neurectomy in patients with resistant Allergic rhinitis by using three different methods ( surgical resection vs radiofrequency ablation vs surface coblation ) through assesment of functional outcomes, postoperative complications, and impacts on quality of life.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-03
• Study First Submitted: 2025-03-09
• Study First Submitted QC: 2025-03-14
• Study First Posted: 2025-03-20
• Study Start: 2025-04
• Last Update Submitted: 2025-04-12
• Last Update Posted: 2025-04-17
• Primary Completion: 2026-04
• Study Completion: 2026-05

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• Patients aged 16 to 65 years, fit for surgery, diagnosed as moderate to severe persistent Allergic Rhinitis, as per the ARIA guidelines having 3 or more of the typical symptoms of Allergic Rhinitis including nasal discharge, repeated attacks of sneezing, nasal itching and nasal obstruction.

Exclusion Criteria

• • Patients with Coexisting nasal pathologies that could influence the outcomes of the surgery like: chronic granulomatous diseases of the nose, nasal tumors, chronic sinsitis with or without nasal polyps, etc.

  • Patients who had used topical steroid nasal spray, oral or topical antihistamines, oral leukotriene antagonists, oral or tobical nasal decongestants in the last 2 weeks.
  • Immunocompromised patients, Systemic disease affecting prognosis such as diabetes mellitus, hypertension,chronic liver failure or heart failure.
  • Unwillingness for endoscopic surgery.
  • Patients younger than 18 years of age.
  • Patients who are unfit for general anesthesia.
  • Previous history of nasal surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Improvement of the four main symptoms (Sneezing ,itching , rhinorrhea ,nasal obstruction)	Evaluations will be scheduled for 2 weeks, one month, three months, and six months following surgery.	These symptoms will be assessed using the SNOT-22 rhinologic subdomain questionnaire which is routinely and prospectively administered to all patients, and individual item scores within the rhinologic subdomain (need to blow nose, sneezing, runny nose, cough, post- nasal discharge, and thick nasal discharge) will be tabulated, each symptom will be scored on a scale from 0 to 5 (0 = no problem, 1 = very mild problem, 2 = mild problem, 3 = moderate problem, 4 = severe problem and 5 = problem as bad as it can be).

Secondary Outcome Measures

Name	Time	Method
postoperative complications eg. Bleeding, crustations etc, postoperative endoscopic score will be evaluated.	2 weeks, 1M month after the procedure .	Bleeding assessment using The Modena bleeding score. Postoperative endoscopic score including : (discharge, crust formation ,scarring ) after the operation will be also recorded and documented using the LundKennedy (LK) system.

Trial Locations

Locations (1)

kafrelsheikh University Hospitals; 🇪🇬 Kafrelsheikh, Egypt