Evaluation of the safety of intra-articular injection of t-SVF in patients with osteoarthritis of the knee: a clinical trial, controlled and phase I

Shahid Beheshti University of Medical Sciences0 个研究点目标入组 20 人开始时间: 待定最近更新: 2023年6月26日

适应症

试验速览

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•Unilateral or bilateral knee osteoarthritis is diagnosed using MRI imaging and is class II, III according to Quaterbridge criteria.
•There is complete damage to the thickness of the cartilage tissue, whose size is less than 1.5 cm in terms of surface.
•WOMAC test of the patient should be less than 8
•The age of the patient should be between 50 and 75
•Body mass index of patients should be between 22 and 37.

•Damage to Minsk
•There is a complete damage to the thickness of the cartilage tissue, which is more than 1.5 cm in terms of surface.
•Osteochondritis dissections
•Parameniscal and Bakers or ganglion cysts
•Lipoma arborescens
•Hoffa'spad syndrome
•Severe swelling and inflammation in the knee area
•Rupture of knee ligaments
•Pain caused by dislocation or fracture of kneecap
•The classification of knee injury should be based on Quterbridge Class IV criteria.
•Classification of knee injury should be based on Quterbridge class IV criteria, but the size of the lesion should be more than 1.5 cm.
•People who have been injected with drugs such as corticosteroids, Vasosupplementation and cell products including SVF, stem cells, platelet-enriched plasma in the last 6 months.
•People who have had knee surgery in the last 6 months.
•People who have a history of systemic diseases, including diabetes, bleeding disorders.
•Women who were pregnant during the study or were planning to become pregnant.
•People who have received oral steroids for a long time.
•History of any chemotherapy or radiation therapy in both parts of the knee and the fat tissue donor area

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