Effect of High-intensity Interval Training Combined With DASH Diet on Arterial Stiffness in Hypertensive Patients: a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Pulse Wave Velocity
研究概览
简要总结
Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide and a major risk factor for morbidity worldwide . It is necessary to reduce the incidence and risk factors of CVD, as physical activity is known to reduce mortality from CVD. Arterial stiffness and hypertension are closely related in pathophysiology. Chronic high blood pressure (BP) can lead to arterial wall damage by mechanical stress, endothelial dysfunction, increased inflammation, oxidative stress, and renin-angiotensin-aldosterone system (RAAS) activation. HIIT has been shown to be equally or even better at stimulating health benefits than moderate-intensity continuous training (MICT) and is considered a time-saving aerobic exercise for reducing arterial stiffness in HTN patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 35 Years 至 50 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Their age< 35 up to 50 years old
- •Both sexes.
- •Controlled HTN ( stage 1,B.P 140-159 mmhg / 90-99 mmhg and stage 2, B.P 160-179 mmhg-100-109 mmhg )
- •Hemodynamic stable. Able to provide informed consent
排除标准
- •Uncontrolled hypertension.
- •Severe HTN <180/110 mmhg
- •Renal dysfunction
- •Unstable cardiac conditions
- •Severe pulmonary disease that limit exercise
- •Impaired cognition
- •Musculoskeletal problems that made it difficult to do exercise
研究组 & 干预措施
DASH diet group
22 patients will receive hypotensive drugs and High Intensity Interval Training ( HIIT) combined with DASH diet.
干预措施: DASH diet (Dietary Supplement)
Comparator group
22 patients will receive hypotensive drugs and High Intensity Interval Training ( HIIT)
干预措施: High Intensity Interval Training (Procedure)
结局指标
主要结局
Pulse Wave Velocity
时间窗: each week
normal level 60-100 per minutes
次要结局
未报告次要终点
