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临床试验/NCT07188272
NCT07188272已完成不适用

Effect of High-intensity Interval Training Combined With DASH Diet on Arterial Stiffness in Hypertensive Patients: a Randomized Controlled Trial

Deraya University1 个研究点 分布在 1 个国家目标入组 66 人开始时间: 2025年7月10日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
66
试验地点
1
主要终点
Pulse Wave Velocity

研究概览

简要总结

Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide and a major risk factor for morbidity worldwide . It is necessary to reduce the incidence and risk factors of CVD, as physical activity is known to reduce mortality from CVD. Arterial stiffness and hypertension are closely related in pathophysiology. Chronic high blood pressure (BP) can lead to arterial wall damage by mechanical stress, endothelial dysfunction, increased inflammation, oxidative stress, and renin-angiotensin-aldosterone system (RAAS) activation. HIIT has been shown to be equally or even better at stimulating health benefits than moderate-intensity continuous training (MICT) and is considered a time-saving aerobic exercise for reducing arterial stiffness in HTN patients

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Investigator)

入排标准

年龄范围
35 Years 至 50 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Their age< 35 up to 50 years old
  • •Both sexes.
  • •Controlled HTN ( stage 1,B.P 140-159 mmhg / 90-99 mmhg and stage 2, B.P 160-179 mmhg-100-109 mmhg )
  • •Hemodynamic stable. Able to provide informed consent

排除标准

  • •Uncontrolled hypertension.
  • •Severe HTN <180/110 mmhg
  • •Renal dysfunction
  • •Unstable cardiac conditions
  • •Severe pulmonary disease that limit exercise
  • •Impaired cognition
  • •Musculoskeletal problems that made it difficult to do exercise

研究组 & 干预措施

DASH diet group

Experimental

22 patients will receive hypotensive drugs and High Intensity Interval Training ( HIIT) combined with DASH diet.

干预措施: DASH diet (Dietary Supplement)

Comparator group

Active Comparator

22 patients will receive hypotensive drugs and High Intensity Interval Training ( HIIT)

干预措施: High Intensity Interval Training (Procedure)

结局指标

主要结局

Pulse Wave Velocity

时间窗: each week

normal level 60-100 per minutes

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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