Incidence and Reasons for Preoperative Anemia in Elective Lower Joint Arthroplasty

• Conditions: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Anemia

• Registration Number: NCT02385409
• Lead Sponsor: Oeivind Jans

Brief Summary

Preoperative anemia is an independent risk factor for the need for allogeneic transfusion during surgery and increased postoperative morbidity.

Treatment of preoperative anemia is recommended. However the type of preoperative anemias in elective hip- and knee surgery has only been sparsely studied.

This observational study aims to investigate the incidence and type of anemias prior to elective hip- and knee arthroplasty.

Detailed Description

Preoperative anemia is an independent risk factor for the need for allogeneic transfusion during surgery and increased postoperative morbidity.

In elective orthopedic surgery, international guidelines recommends treatment of preoperative anemia including the use of Iron supplements for anemias associated with iron deficiency. In addition, low iron stores in both anemic and non-anemic patients may delay postoperative hemoglobin recovery.

However, the reasons for preoperative anemia and the prevalence of patients with low iron stores have only been sparsely studied in elective hip- and knee arthroplasty.

This observational study aims to investigate the incidence and type of anemias prior to elective hip- and knee arthroplasty.

Study Timeline

• Study Start: 2013-05
• Primary Completion: 2014-05
• Study First Submitted: 2015-02-16
• Status Verified: 2015-03
• Study First Submitted QC: 2015-03-05
• Last Update Submitted: 2015-03-05
• Study First Posted: 2015-03-11
• Last Update Posted: 2015-03-11
• Study Completion: 2015-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 900

Inclusion Criteria

• Age > 18 years
• Scheduled for elective primary hip- or knee replacement.

Exclusion Criteria

• Not possible to obtain preoperative blood sample.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Anemia Classification - Biochemical classification from preoperative venous blood samples	Date of preoperative blood sampling	Biochemical classification from preoperative venous blood samples

Secondary Outcome Measures

Name	Time	Method
Prevalence of Anemia according to WHO definitions	Date of preoperative blood sampling	According to WHO definitions
Proportions of non-anemic patients with low irons stores	Date of preoperative blood sampling	Low Ferritin or Transferin saturation (TSAT)

Trial Locations

Locations (1)

Hvidovre Hospital, Department of orthopaedic surgery; 🇩🇰 Hvidovre, Denmark