Inflammatory cytokine production in primary total knee arthroplasty
Phase 4
Completed
- Conditions
- Inflammatory cytokine production in primary total knee arthroplastyinflammatory cytokineprimary total knee arthroplastyconventional techniquecomputer-assisted technique
- Registration Number
- TCTR20210224007
- Lead Sponsor
- avamindradhiraj University Research Fund
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1. age 56 to 75 years diagnosed with primary knee osteoarthritis
2. radiograph knee show Kellgren, Lawrence score III to IV
3. staged bilateral knee arthroplasty at least 6 months
Exclusion Criteria
1. previous knee surgery
2. previous or recent knee infection
3. underlying disease with cerebrovascular and neuromuscular that affected knee function
4. liver disease, malnutrition, hypoalbuminemia
5. lung complication
6. ESRD, autoimmune disease
7. NSAIDs allergy
8. history of hyaluronic acid usage within 6 months
9. systemic NSAIDs within 15 days
10. drug abuse and alcohol usage within 3 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method serum interleukin-6 baseline, 24 h, 72 h, 2 wks pg/ml,joint interleukin-6 baseline, 24 h pg/L,serum ESR baseline, 24 h, 72 h, 2 wks mm/hr,serum CRP baseline, 24 h, 72 h, 2 wks mg/L,joint CRP baseline, 24 h mg/L,skin temperature of knee baseline, 72 h, 2 wks Celsius
- Secondary Outcome Measures
Name Time Method KOOS 2 wks score