Effectiveness of preinduction ketamine versus magnesium sulphate nebulization on the incidence of sore throat after general endotracheal anesthesia: A prospective randomized double blind comparative study.
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- To compare efficacy of ketamine nebulization versus magnesium sulphate nebulization on incidence post operative sore throat
研究概览
简要总结
Postoperative sore throat (POST) is a well-recognized complication which is remaining unsolved, contributing to postoperative morbidity and patient’s dissatisfaction with reported incidence of 6.6 to 90% in different studies worldwide. It also increased the duration of hospital stay, especially in a day care procedure.
Both pharmacological and non-pharmacological measures have been used for attenuating POST.
Pharmacological measures for attenuating POST includes inhalation of beclomethasone and fluticasone, gargling with azulene sulfonate, ketamine, benzadymine hydrochloride, and intra cuff administration of alkalinized lignocaine etc.
It is known that N-methyl-D-aspartate (NMDA) has a role in nociception and inflammation. NMDA receptors are found in peripheral nerves and the central nervous system.
NMDA receptors antagonist such as magnesium sulphate, ketamine (phencyclidine derivative) has been used independently as pre operative nebulization in reducing POST.
In present study,we would like to find out the effectiveness of pre induction ketamine nebulization versus magnesium sulphate nebulization on incidence of POST.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged 18 to 65 years.
- •Patients with American Society of Anesthesiologists (ASA) physical status I to III 3)Patients with Mallampati grade (MPG) I to III 4)Patients scheduled to undergo elective surgery of 4 hours duration who requires general endotracheal anesthesia.
排除标准
- •Patients having history of preoperative sore throat or recent upper respiratory tract infection.
- •Patients undergoing oral surgeries, neck surgeries like thyroid surgery.
- •Patients with known allergy to study drug.
- •Hypertensive patients.
- •Patients with raised renal parameters.
- •Patients requiring more than 3 attempts at intubation.
- •Pregnant and lactating women.
- •Patients not willing to give consent.
结局指标
主要结局
To compare efficacy of ketamine nebulization versus magnesium sulphate nebulization on incidence post operative sore throat
时间窗: at induction, 2 hours, 4 hours, 6 hours and 12 hours
次要结局
- 1.Incidence of postoperative cough and hoarseness of voice(2.Severity of postoperative sorethroat)
研究者
Dr Bhumireddy Anusha
Sri venkateswara institute of medical sciences(SVIMS)