Water-and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease, Evaluated by the Excretion of Aquaporin-2 and Epithelial Sodium Channels in the Urine
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Differences in excretion of Aquaporin-2 in urine
研究概览
简要总结
The purpose of the study is to determine whether the excretion of renal water- and salt-channels in the urine reflects the handling of water and salt in the kidneys, and whether the excretion can be used to monitor and/or predict the effects of treatment of certain heart or lung diseases.
详细描述
The purpose of the study is to determine whether the excretion of renal water- and salt-channels (Aquaporin-2 and Epithelial Sodium Channels) in the urine accurately reflects the handling of water and salt in the distal tubules af the kidneys, and whether quantification of these channels in the urine is useful to monitor and/or predict the effects of pharmacologic or surgical treatment of Heart Failure and heart failure-related diseases (Aortic stenosis, acute and chronic ischemic heart disease or pulmonary hypertension)
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Symptomatic heart failure
- •Severe valvular aortic stenosis
- •Acute Coronary Syndrome
- •Medically refractory chronic angina pectoris or pulmonary hypertension with preserved left ventricular function
排除标准
- •Pregnancy
- •Drug abuse
- •Malignant disease
- •Significant disease of other organs including endocrine diseases
研究组 & 干预措施
2
Patients with symptomatic heart failure and EF < 40%
干预措施: Pharmacologic and mechanical heart failure treatment (Drug)
3
Patients with symptomatic aortic valve stenosis
干预措施: Aortic valve replacement (Procedure)
4
Patients with Acute Coronary syndromes prior to surgical intervention
干预措施: Revascularisation in Acute Coronary Syndrome (Procedure)
5
Patients with refractory stable angina requiring surgical intervention.
干预措施: Revascularisation in chronic stable angina pectoris (Procedure)
结局指标
主要结局
Differences in excretion of Aquaporin-2 in urine
时间窗: 6 months
次要结局
- Differences in excretion of Epithelial Sodium Channels in urine(6 months)