Long Term Sequelae of COVID-19: Observational Cohort Study in Twente, the Netherlands
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Long COVID-19
- Sponsor
- Medisch Spectrum Twente
- Enrollment
- 835
- Locations
- 1
- Primary Endpoint
- General health perception
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has a devastating effect on human lives, including over 6.6 million death as of November 2022. Furthermore, many individuals continue to experience persisting sequelae after the initial infection. Little is known about the impact of undergoing COVID-19 hospitalisation. Hence, the investigators propose an observational longitudinal study in a cohort of COVID-19 survivors after hospital discharge, to examine their perspectives on their health, health-related quality of life, and persistence of common COVID-19 symptoms, such as fatigue, dyspnoea and anxiety. Potential influencing socio-demographic and biological factors will additionally assessed.
Investigators
Harald E. Vonkeman
Principle Investigator
Medisch Spectrum Twente
Eligibility Criteria
Inclusion Criteria
- •Ages ≥18 years
- •PCR-confirmed SARS-CoV-2 infection and hospital admission
- •Proficiency in Dutch
- •Providing informed consent
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
General health perception
Time Frame: at 12 months after hospital discharge
measured by Short Form 36 Health Survey (SF-36)
Secondary Outcomes
- Health Status Scale(at 3, 6, 9 and 12 months)
- Experience sampling study measuring fatigue(Six times a day over 14 days)
- Incidence, severity and course of Post-Traumatic Stress Disorder(at 3, 6, 9 and 12 months)
- Experience sampling study measuring severity and daily course of positive and negative affect(Six times a day over 14 days)
- Positive Health(at 3, 6, 9 and 12 months)
- Incidence, severity and course of Dyspnoea(at 3, 6, 9 and 12 months)
- Incidence, severity and course of Sleep(at 3, 6, 9 and 12 months)
- Experience sampling study measuring health status(Once a day for 14 days)
- Health Status(at 3, 6, 9 and 12 months)
- Experience sampling study measuring pain(Six times a day over 14 days)
- Health-related quality of life(at 3, 6, 9 and 12 months)
- Incidence, severity and course of Fatique(at 3, 6, 9 and 12 months)
- Experience sampling study measuring dyspnoea(Six times a day over 14 days)
- Experience sampling study measuring cognitive functioning(Six times a day over 14 days)
- Experience sampling study measuring naps(Once a day for 14 days)
- Experience sampling study measuring daily activity(Six times a day over 14 days)
- Experience sampling study measuring sleep(Once a day for 14 days)