Splenda: Effects on Blood Glucose Concentration, Appetite Scores and Subsequent Energy Intake

Not Applicable

Completed

• Conditions: Glucose Metabolism Disorders; Appetitive Behavior
• Interventions: Dietary Supplement: Splenda drink; Dietary Supplement: Maltodextrin drink; Dietary Supplement: High carbohydrate breakfast

• Registration Number: NCT05810337
• Lead Sponsor: King's College London

Brief Summary

This study investigates the effects of Splenda, an artificial sweetener powder containing sucralose, on post-prandial blood glucose levels, appetite scores and subsequent energy intake.

Detailed Description

Participants are randomly assigned to receive either the placebo drink (4.5g maltodextrin dissolved in 250ml water) or the Splenda drink (4.5g Splenda dissolved in 250ml water) taken alongside a high calorie breakfast.

Blood glucose measurements will be obtained through finger-pricking and appetite will be measured using self-reported visual analogue scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast. Energy intake will be measured using a 24 hour food diary.

Study Timeline

• Study Start: 2023-01-18
• Primary Completion: 2023-02-01
• Status Verified: 2023-03
• Study Completion: 2023-03-13
• Study First Submitted: 2023-03-30
• Study First Submitted QC: 2023-03-30
• Last Update Submitted: 2023-03-30
• Study First Posted: 2023-04-12
• Last Update Posted: 2023-04-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• Healthy male and female adults (18-64 years)

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Splenda drink	Splenda drink	Drink containing 4.5g Splenda dissolved on 250ml water.
Splenda drink	High carbohydrate breakfast	Drink containing 4.5g Splenda dissolved on 250ml water.
Maltodextrin drink	Maltodextrin drink	Drink containing 4.5g maltodextrin dissolved on 250ml water.
Maltodextrin drink	High carbohydrate breakfast	Drink containing 4.5g maltodextrin dissolved on 250ml water.

Primary Outcome Measures

Name	Time	Method
Change in blood glucose	-5 to 180 minutes (measured from baseline up to 90min every 15min and from 90-180min every 30min)	Capillary blood glucose from fingerprick and measured using glucose monitor
Change in appetite	-5 to 180 minutes (measured from baseline up to 90min every 15min and from 90-180min every 30min)	Feelings of hunger, desire to eat, fullness and alertness measured using Visual Analogue Scale (VAS)

Secondary Outcome Measures

Name	Time	Method
24 hour energy intake	0 - 24 hours	Food intake over the 24 hours of the study day using a 24 hour food diary entered into dietary analysis software

Trial Locations

Locations (1)

King's College London; 🇬🇧 London, United Kingdom